Results 201 to 210 of about 1,692,892 (304)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Total Thrombus-Formation Analysis System (T-TAS) in Aortopathies: A Conceptual and Potential Framework to Spatial Heterogeneity and Regional Context. [PDF]

Int J Mol Sci
Krych S, Gniewek J, Kolbowicz M, Stępień-Słodkowska M, Adamczyk M, Hrapkowicz T, Kowalczyk P.   +6 more
europepmc   +1 more source

Crack growth plasticity condensed model and T-stress influence

, 2017
Les divers composants d'un réacteur d'avion sont soumis à des chargements de fatigue mécaniques et thermiques fortement variables. Afin de prédire au mieux leurs durées de vie, il est alors nécessaire de prendre en compte l'ensemble de ces variations. Pour ce faire, un modèle représentant de façon incrémentale l'évolution de la plasticité en pointe de ...
openaire   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

<i>Terminalia arjuna</i> Switches from Adaptive to Survival Strategy Under Severe Water Stress. [PDF]

Plants (Basel)
Jui LA, Chowdhury T, Ador MAH, Khatun R, Haque MMU, Dey B, Ahmed R.   +6 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

ZmSKIP enhances drought tolerance by reducing stomatal aperture in maize. [PDF]

PLoS Genet
Wang Y, Zhou Y, Li Q, Zhang Y, Yang L, Zhou Q, Xu W, Liu T, Liu Y, Wu F, Sun G, Guo W, Lu Y, Xu J.   +13 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Bioprospection of entomopathogenic fungi natives of Brazilian Semi-arid with potential for biological control of Insect-pests. [PDF]

World J Microbiol Biotechnol
Santos TS, de Almeida Santos JF, Santos ELT, Santos TS, Leite JLS, Blank AF, Mendonça MDC.   +6 more
europepmc   +1 more source