Results 201 to 210 of about 5,016,758 (248)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Correction: Targeting the CAF-GDF15 axis attenuates AKT-mediated mitochondrial rewiring and chemoradiation resistance in esophageal adenocarcinoma. [PDF]

J Exp Clin Cancer Res
Fan N, Deng P, Wang Z, Ju F, Raatz L, Velazquez Camacho O, Hillmer AM, Odenthal M, Nguyen PH, Lyu Z, Popp F, Chon SH, Bijlsma MF, Ros R, van Laarhoven HWM, Quaas A, Wischhusen J, Zhao Y, Bruns CJ.   +18 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Negative Affective States Are Not Detected in Rats Following an Intravenous Self-Administration Regimen Leading to Incubation of Oxycodone Craving. [PDF]

Addict Biol
Wunsch AM, Mount KA, Guzman A, Kawa AB, Westlake JG, Kuhn HM, Beutler MM, Wolf ME.   +7 more
europepmc   +1 more source

Low-Intensity Focused Ultrasound Enables Temporal Modulation of Human Midbrain Organoid Differentiation. [PDF]

Adv Sci (Weinh)
Jeong J, Jo Y, Lee Y, Jang E, Jeong Y, Heo WD, Shin JH, Lee MO, Lee HJ.   +8 more
europepmc   +1 more source

Transcriptional alterations in SKAP1-associated inside-out signaling in CNS-infiltrated pediatric T-cell acute lymphoblastic leukemia. [PDF]

Cell Death Discov
Enlund S, Papadakis K, Short J, Hermanson O, Nilsson A, Jiang Q, Holm F.   +6 more
europepmc   +1 more source

Arhgef1 Deletion Disrupts Early Cortical Neurogenesis via PAK1 Overactivation and Causes Motor Dysfunction in Adulthood. [PDF]

Adv Sci (Weinh)
Li L, Ma X, Ding Z, Sun B, Liu L, Yip HM, Wang W, Wu T, Guo Y, Peng Y, Zhang S, Ip JPK, Zhang L, Li K, Shi L.   +14 more
europepmc   +1 more source