Results 1 to 10 of about 11,262 (230)

Multiple pathways of plasmid DNA transfer in Helicobacter pylori. [PDF]

PLoS ONE, 2012
Many Helicobacter pylori (Hp) strains carry cryptic plasmids of different size and gene content, the function of which is not well understood. A subgroup of these plasmids (e.g.
Stefanie Rohrer, Lea Holsten, Evelyn Weiss, Mohammed Benghezal, Wolfgang Fischer, Rainer Haas   +5 more
doaj   +15 more sources

A bacterial toxin-antitoxin module is the origin of inter-bacterial and inter-kingdom effectors of Bartonella. [PDF]

PLoS Genetics, 2017
Host-targeting type IV secretion systems (T4SS) evolved from conjugative T4SS machineries that mediate interbacterial plasmid transfer. However, the origins of effectors secreted by these virulence devices have remained largely elusive.
Alexander Harms, Marius Liesch, Jonas Körner, Maxime Québatte, Philipp Engel, Christoph Dehio   +5 more
doaj   +7 more sources

Functional plasticity in the type IV secretion system of Helicobacter pylori. [PDF]

PLoS Pathogens, 2013
Helicobacter pylori causes clinical disease primarily in those individuals infected with a strain that carries the cytotoxin associated gene pathogenicity island (cagPAI).
Roberto M Barrozo, Cara L Cooke, Lori M Hansen, Anna M Lam, Jennifer A Gaddy, Elizabeth M Johnson, Taryn A Cariaga, Giovanni Suarez, Richard M Peek, Timothy L Cover, Jay V Solnick   +10 more
doaj   +4 more sources

Campylobacter fetus Subspecies Contain Conserved Type IV Secretion Systems on Multiple Genomic Islands and Plasmids. [PDF]

PLoS ONE, 2016
The features contributing to differences in pathogenicity of the Campylobacter fetus subspecies are unknown. Putative factors involved in pathogenesis are located in genomic islands that encode a type IV secretion system (T4SS) and fic domain ...
Linda van der Graaf-van Bloois, William G Miller, Emma Yee, Gregor Gorkiewicz, Ken J Forbes, Aldert L Zomer, Jaap A Wagenaar, Birgitta Duim   +7 more
doaj   +8 more sources

The assembly of a hybrid type IV secretion system by a Crohn’s disease-associated Escherichia coli strain [PDF]

Nature Communications
Type IV secretion systems (T4SSs) are central to bacterial pathogenesis. Traditionally known for facilitating DNA transfer via conjugation, T4SSs also mediate biofilm formation. These biofilms are critical for the fitness of adherent-invasive Escherichia
Jonas Wong, Ahmad Refaat, Pablo Villacampa-Teixeira, Jonasz B. Patkowski, Natalie Lapa, Julian Ortiz, Kasia Dzierlega, Blake Roberts, Stephanie Tollenaar, Matthew Croxen, Aducio Thiesen, Dina Kao, Ben Willing, Xavier Clemente-Casares, Tiago R. D. Costa, Wael Elhenawy   +15 more
doaj   +2 more sources

Type IV secretion systems: from structures to mechanisms [PDF]

The EMBO Journal
Bacterial conjugation is the fundamental process of unidirectional transfer of DNA from a “donor” cell to a “recipient” cell. It is the primary means by which antibiotic resistance genes spread among bacterial populations.
Pierre Paillard, Quentin Rouger, Manon Thomet, Kévin Macé   +3 more
doaj   +2 more sources

In Vivo Structures of the Helicobacter pylori cag Type IV Secretion System [PDF]

Cell Reports, 2018
Summary: The type IV secretion system (T4SS) is a versatile nanomachine that translocates diverse effector molecules between microbes and into eukaryotic cells. Here, using electron cryotomography, we reveal the molecular architecture of the Helicobacter
Yi-Wei Chang, Carrie L. Shaffer, Lee A. Rettberg, Debnath Ghosal, Grant J. Jensen   +4 more
doaj   +6 more sources

Bacterial type IV secretion system induces specific and nonspecific protective immunity [PDF]

mBio
Pathogenic microbes trigger rapid and robust innate immune responses that effectively restrict pathogen replication and promote long-lasting adaptive immunity.
Fernanda V. S. Castanheira, Marcelo S. F. Pereira, Marco A. Ataide, Danielle P. A. Mascarenhas, Rhanoica O. Guerra, Gustavo F. S. Quirino, Fausto Almeida, Dario S. Zamboni   +7 more
doaj   +2 more sources

Species-specific components of the Helicobacter pylori Cag type IV secretion system [PDF]

Infection and Immunity
Helicobacter pylori strains containing the cag pathogenicity island (PAI) deliver an effector protein (CagA) and non-protein substrates into gastric cells through a process that requires the Cag type IV secretion system (T4SS).
Kaeli N. Bryant, Arwen E. Frick-Cheng, Lauren E. Solecki, Heather K. Kroh, W. Hayes McDonald, D. Borden Lacy, Mark S. McClain, Melanie D. Ohi, Timothy L. Cover   +8 more
doaj   +2 more sources

Helicobacter pylori CagA and Cag type IV secretion system activity have key roles in triggering gastric transcriptional and proteomic alterations [PDF]

Infection and Immunity
Colonization of the human stomach with cag pathogenicity island (PAI)-positive Helicobacter pylori strains is associated with increased gastric cancer risk compared to colonization with cag PAI-negative strains.
Jennifer H. B. Shuman, Aung Soe Lin, Mandy D. Westland, Kaeli N. Bryant, Gabrielle E. Fortier, M. Blanca Piazuelo, Michelle L. Reyzer, Audra M. Judd, Tina Tsui, W. Hayes McDonald, Mark S. McClain, Kevin L. Schey, Holly M. Algood, Timothy L. Cover   +13 more
doaj   +2 more sources