Results 91 to 100 of about 11,262 (230)

Identification of non-dot/icm suppressors of the Legionella pneumophila △dotL lethality phenotype [PDF]

, 2006
Legionella pneumophila, a causative agent of bacterial pneumonia, survives inside phagocytic cells by avoiding rapid targeting to the lysosome. This bacterium utilizes a type IVB secretion system, encoded by the dot/icm genes, to replicate inside host ...
Bardill, Patrick, Buscher, Benjamin A., Friedman, Jonathan R., Vincent, Carr D., Vogel, Joseph P., Williams, Lee Anne   +5 more
core   +3 more sources

Helicobacter pylori and Inflammatory Bowel Disease: Unraveling the Complex Interactions and Clinical Implications

JGH Open, Volume 9, Issue 12, December 2025.
ABSTRACT Helicobacter pylori infection has been extensively studied in relation to various gastrointestinal disorders, with emerging evidence suggesting a significant association with inflammatory bowel disease (IBD). Epidemiological studies consistently demonstrate an inverse relationship between H.
Elaheh Karimzadeh‐Soureshjani, Farab Pourhasan, Pouria Ahmadi Simab, Nabi Jomehzadeh, Ali Saeedi‐Boroujeni   +4 more
wiley   +1 more source

The Polar Legionella Icm/Dot T4SS Establishes Distinct Contact Sites with the Pathogen Vacuole Membrane

mBio, 2021
Legionnaires’ disease is a life-threatening pneumonia, which is characterized by high fever, coughing, shortness of breath, muscle pains, and headaches. The disease is caused by the amoeba-resistant bacterium L. pneumophila found in various soil and aquatic environments and is transmitted to humans via the ...
Böck, Désirée, Hüsler, Dario, Steiner, Bernhard, Medeiros, João M., Welin, Amanda, Radomska, Katarzyna A., Hardt, Wolf-Dietrich, Pilhofer, Martin, Hilbi, Hubert   +8 more
openaire   +5 more sources

AtlasT4SS: A curated database for type IV secretion systems

BMC Microbiology, 2012
Background The type IV secretion system (T4SS) can be classified as a large family of macromolecule transporter systems, divided into three recognized sub-families, according to the well-known functions.
Souza Rangel C, del Rosario Quispe Saji Guadalupe, Costa Maiana OC, Netto Diogo S, Lima Nicholas CB, Klein Cecília C, Vasconcelos Ana Tereza R, Nicolás Marisa F   +7 more
doaj   +1 more source

An optimal set of features for predicting type IV secretion system effector proteins for a subset of species based on a multi-level feature selection approach. [PDF]

PLoS ONE, 2018
Type IV secretion systems (T4SS) are multi-protein complexes in a number of bacterial pathogens that can translocate proteins and DNA to the host. Most T4SSs function in conjugation and translocate DNA; however, approximately 13% function to secrete ...
Zhila Esna Ashari, Nairanjana Dasgupta, Kelly A Brayton, Shira L Broschat   +3 more
doaj   +1 more source

The inhibition of the apoptosis pathway by the Coxiella burnetii effector protein CaeA requires the EK repetition motif, but is independent of survivin [PDF]

, 2016
Coxiella burnetii is an obligate intracellular bacterium that causes Query (Q) fever, a zoonotic disease. It requires a functional type IV secretion system (T4SS) which translocate bacterial effector proteins into the host cell cytoplasm and thereby ...
Bisle, Stephanie, Borges, Vítor, Gomes, João Paulo, Heydel, Carsten, Klingenbeck, Leonie, Lührmann, Anja, Menge, Christian, Schulze-Luehrmann, Jan, Sobotta, Katharina   +8 more
core   +1 more source

Phylogeny, Synteny, and Distribution of Type III Secretion Systems in Burkholderia cenocepacia: A Closer Look Into Host Span

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
T3SS is a dedicated machinery that mediates interactions between bacteria and eukaryotic cells, providing a functional interface in pathogenic or symbiotic associations. Phylogenetic analyses and T3SS‐gene synteny revealed nine gene clusters, with no needle protein gene (sctF). However, an orphan CDS encoding a putative SctF was found.
Gabrielle Tomé Cordeiro, Hadassa Loth de Oliveira, Danielly C. O. Mariano, Yasmin Salazar Torres, Graciela Maria Dias, Bianca C. Neves   +5 more
wiley   +1 more source

A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System

mBio, 2022
Bacterial type IV secretion systems (T4SSs) are macromolecular machines that translocate effector proteins across multiple membranes into infected host cells.
Eric Cheng, Dorjbal Dorjsuren, Stephanie Lehman, Charles L. Larson, Steven A. Titus, Hongmao Sun, Alexey Zakharov, Ganesha Rai, Robert A. Heinzen, Anton Simeonov, Matthias P. Machner   +10 more
doaj   +1 more source

“Expanding the Lactococcal Cell Wall Polysaccharide Paradigm: Novel Structures and Metabolic Pathways in the Emerging Dairy Species Pseudolactococcus laudensis and Pseudolactococcus raffinolactis”

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study characterizes the genetic diversity of Pseudolactococcus laudensis and Pseudolactococcus raffinolactis regarding cell wall polysaccharides (CWPS) and exopolysaccharide (EPS) biosynthesis, uncovering novel genotypes and biosynthetic pathways.
Axel Soto‐Serrano, Irina Sadovskaya, Evgeny Vinogradov, Wenwen Li, Jun‐Hyeok Yu, Kelsey White, Douwe van Sinderen, Lukasz Krych, Paulina Deptula, Jennifer Mahony   +9 more
wiley   +1 more source

The opportunistic pathogen Stenotrophomonas maltophilia utilizes a type IV secretion system for interbacterial killing.

PLoS Pathogens, 2019
Bacterial type IV secretion systems (T4SS) are a highly diversified but evolutionarily related family of macromolecule transporters that can secrete proteins and DNA into the extracellular medium or into target cells. It was recently shown that a subtype
Ethel Bayer-Santos, William Cenens, Bruno Yasui Matsuyama, Gabriel Umaji Oka, Giancarlo Di Sessa, Izabel Del Valle Mininel, Tiago Lubiana Alves, Chuck Shaker Farah   +7 more
doaj   +1 more source