Results 111 to 120 of about 11,262 (230)

Coxiella burnetii Blocks Intracellular Interleukin-17 Signaling in Macrophages [PDF]

, 2018
Coxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever. Successful host cell infection requires the Coxiella type IVB secretion system (T4BSS), which translocates bacterial effector proteins across the vacuole ...
Clemente, Tatiana M., Gilk, Stacey D., Justis, Anna V., Mulye, Minal, Nallandhighal, Srinivas, Tran, Tuan M.   +5 more
core   +1 more source

The Type IV Secretion System (T4SS) Mediates Symbiosis between Bradyrhizobium sp. SUTN9-2 and Legumes [PDF]

, 2023
Praneet Wangthaisong, Pongdet Piromyou, Pongpan Songwattana, Jenjira Wongdee, Kamonluck Teamtaisong, Panlada Tittabutr, Nantakorn Boonkerd, Neung Teaumroong   +7 more
openalex   +1 more source

Xanthomonas immunity proteins protect against the cis-toxic effects of their cognate T4SS effectors

EMBO Reports
AbstractMany bacteria kill rival species by translocating toxic effectors into target cells. Effectors are often encoded along with cognate immunity proteins that could (i) protect against “friendly-fire” (trans-intoxication) from neighboring sister cells and/or (ii) protect against internal cis-intoxication (suicide).
Gabriel Umaji Oka, Diorge P. Souza, Germán G. Sgro, Cristiane Rodrigues Guzzo, Germán Dunger, Chuck S. Farah   +5 more
openalex   +4 more sources

Research advancements and evaluation of multifactor‐induced murine models for gastric cancer

Animal Models and Experimental Medicine, Volume 8, Issue 11, Page 1923-1934, November 2025.
Murine models for gastric cancer. Abstract As one of the most prevalent gastrointestinal malignancies in humans, gastric cancer (GC) is often detected at an advanced stage, resulting in a poor prognosis and ranking it the fifth leading cause of cancer‐related deaths.
Yiqing Wang, Liang Zhang, Weixu Feng, Wanfeng Liu, Xiangyang Xue, Shiyu Feng   +5 more
wiley   +1 more source

Conjugative type IV secretion systems enable bacterial antagonism that operates independently of plasmid transfer

Communications Biology
Bacterial cooperation and antagonism mediated by secretion systems are among the ways in which bacteria interact with one another. Here we report the discovery of an antagonistic property of a type IV secretion system (T4SS) sourced from a conjugative ...
Lois Gordils-Valentin, Huanrong Ouyang, Liangyu Qian, Joshua Hong, Xuejun Zhu   +4 more
doaj   +1 more source

OrfG, a VirB8-like protein encoded by an integrative and conjugative element in Streptococcus thermophilus, has a trimeric architecture with intertwined subunits that may be involved in the Gram-positive Conj-T4SS [PDF]

, 2021
Julien Cappèle, Badreddine Douzi, Sandrine Mathiot, Nathalie Leblond‐Bourget, Claude Didierjean, F. Favier   +5 more
openalex   +1 more source

Research Advances of the Effects of Food and Medicine Homology Substances on Gastric Cancer

Cancer Medicine, Volume 14, Issue 19, October 2025.
ABSTRACT Background Gastric cancer (GC), a common malignant tumor, poses a significant threat to human health. Conventional radiotherapy and chemotherapy regimens come with significant drawbacks, including high toxicity, adverse side effects, inadequate targeting ability, and the potential for developing drug resistance, which ultimately diminishes ...
Zhengyang Hao, Xiangjun Chen, Wenqian Tang, Ruipeng Wu, Bei Xue, Jingzhe Chen, Yidan Zhang, Shaokang Wang   +7 more
wiley   +1 more source

Population gene introgression and high genome plasticity for the zoonotic pathogen Streptococcus agalactiae [PDF]

, 2019
The influence that bacterial adaptation (or niche partitioning) within species has on gene spillover and transmission among bacteria populations occupying different niches is not well understood.
Abbott, Abby, Almeida, Baily, Bankevich, Beerli, Beerli, Benjamini, Bertels, Bikard, Bisharat, Bishop, Bohnsack, Borchardt, Brett M Probert, Brochet, Bruen, Brynildsrud, Capella-Gutierrez, Chen, Chen, Cheng, Chiara Crestani, Chopra, Christopher D Town, Conrad, Croucher, Da Cunha, Delannoy, Delannoy, Dogan, Edgar, Enright, Erwin, Fernandez, Ferreira, Flores, Fluegge, Garrett H Springer, Gauthier, Glazko, Glazko, Greig, Guglielmini, Gupta, Hayley B Hassler, Heaps, Holt, Imperi, Inouye, Irina M Velsko, Jafar, Jaskowiak, Jeukens, Johri, Jones, Jones, Jorgensen, Joubrel, Kalimuddin, Kim, Konig, Langdon, Librado, Lin, Lindahl, Liu, Liu, Lopez-Sanchez, Loytynoja, Lyhs, Manning, Manning, Martins, Marttinen, Mather, McArthur, Md Tauqeer Alam, Michael J Stanhope, Morse, Murrell, Page, Pal, Paulina D Pavinski Bitar, Pedersen, Petrovska, Pond, Poyart, Price, Qin, Richards, Richards, Richards, Rosinski-Chupin, Ruth N Zadoks, Sahl, Sahl, Sahl, Scheffer, Schrieber, Seemann, Shannon D Manning, Shapiro, Shepheard, Sheppard, Spoor, Springman, Srivastava, Stamatakis, Stoddard, Sukhnanand, Supek, Tettelin, Tettelin, Tian, van der Mee-Marquet, Verani, Viana, Vincent P Richards, Yu, Zadoks, Zankari, Zerbino, Zhang, Zhu   +124 more
core   +2 more sources

The Role of Phyllosphere Microbes and Viruses in Biocontrol of Pathogenic Fungi

Microbial Biotechnology, Volume 18, Issue 10, October 2025.
Foliar microbiota employ multiple ecological strategies to inhibit fungal pathogens in the phyllosphere, including resource competition, production of antifungal metabolites, contact‐dependent killing, modulation of plant innate immunity and mycovirus‐mediated suppression.
Li Bi, Zahra F. Islam, Lok‐Hang Chan, Hang‐Wei Hu   +3 more
wiley   +1 more source

Structural studies of T4S systems by electron microscopy [PDF]

, 2015
: Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNA and/or proteins through the membranes of bacteria. Analysis of T4S system architecture is an extremely challenging task taking into account their multi protein ...
Abdallah AM, Gey van Pittius NC, Champion PA, et a, Backert S, Meyer TF, Bailey S, Ward D, Middleton R, et al., Banta LM, Kerr JE, Cascales E, et al., Cascales E, Cascales E, Christie PJ, Cascales E, Christie PJ, Christie PJ, Atmakuri K, Krishnamoorthy V, et al., Christie PJ, Cascales E, Clemens DL, Ge P, Lee BY, et al., Cornelis GR, Van Gijsegem F, De Carlo S, Harris JR, de Jong MF, Sun YH, den Hartigh AB, et al., Dubochet J, Durand E, Waksman G, Receveur-Brechot V, Eisenbrandt R, Kalkum M, Lai EM, et al., Filloux A, Fronzes R, Christie PJ, Waksman G, Fronzes R, Schafer E, Wang L, et al., Gomis-Ruth FX, Moncalian G, Perez-Luque R, et al., Henderson IR, Navarro-Garcia F, Desvaux M, et al., Hofreuter D, Karnholz A, Haas R, Jakubowski SJ, Kerr JE, Garza I, et al., Jakubowski SJ, Krishnamoorthy V, Cascales E, et al, Judd PK, Mahli D, Das A, Kerr JE, Christie PJ, Kudryashev M, Wang RY, Brackmann M, et al., Lederberg J, Tatum EL, Lessl M, Lanka E, Li X, Mooney P, Zheng S, et al., Llosa M, de la Cruz F, Low HH, Gubellini F, Rivera-Calzada A, et al., McMullan G, Faruqi AR, Henderson R, et al., Mossey P, Hudacek A, Das A, Ninio S, Roy CR, Orlova EV, Saibil HR, Pansegrau W, Lanka E, Pena A, Matilla I, Martin-Benito J, et al., Ripoll-Rozada J, Zunzunegui S, de la Cruz F, et al, Rivera-Calzada A, Fronzes R, Savva CG, et al., Savvides SN, Yeo HJ, Beck MR, et al., Schraidt O, Marlovits TC, Schroder G, Krause S, Zechner EL, et al., Sivanesan D, Baron C, Terradot L, Bayliss R, Oomen C, et al., Trokter M, Felisberto-Rodrigues C, Christie PJ, et, Wallden K, Williams R, Yan J, et al., Yeo HJ, Savvides SN, Herr AB, et al., Yeo HJ, Yuan Q, Beck MR, et al., Yuan Q, Carle A, Gao C, et al., Zechner EL, Lang S, Schildbach JF   +50 more
core   +2 more sources