Results 11 to 20 of about 11,262 (230)
Structure and Function of the Dot/Icm T4SS [PDF]
, 2023 AbstractTheLegionella pneumophilaDot/Icm type IV secretion system (T4SS) delivers effector proteins into host cells during infection. Despite its significance as a potential drug target, our current understanding of its atomic structure is limited to isolated subcomplexes.
Przemysław Dutka +9 more
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An intracellular nanobody targeting T4SS effector inhibits Ehrlichia infection [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance Disease-relevant targets of infection by obligatory intracellular pathogens are beyond the reach of conventional antibodies. The neutralizing targets of intracellular pathogens in host cells are mostly unknown. The present study attempted to overcome these limitations with a combination of nanobodies, transfection ...
Wenqing Zhang +10 more
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Bacterial communication mediated by T4SS effectors [PDF]
Phytopathology Research, 2023 AbstractBacteria have the ability to inhibit the growth of competitors by using contact-dependent killing devices, such as the bacterial-killing type IV secretion system (T4SS). A recent publication in The ISME Journal by Wang et al. (ISME J, 2023.
Lei Xu, Xihui Shen
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Identification of atypical T4SS effector proteins mediating bacterial defense [PDF]
mLife, 2023 AbstractTo remain competitive, proteobacteria use various contact‐dependent weapon systems to defend against microbial competitors. The bacterial‐killing type IV secretion system (T4SS) is one such powerful weapon. It commonly controls the killing/competition between species by secreting the lethal T4SS effector (T4E) proteins carrying conserved XVIPCD
Xi Shen +11 more
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Design of multi-epitope vaccine candidate against Brucella type IV secretion system (T4SS) [PDF]
PLOS ONE, 2023 Brucellosis is a common zoonosis, which is caused by Brucella infection, and Brucella often infects livestock, leading to abortion and infertility. At present, human brucellosis remains one of the major public health problems in China. According to previous research, most areas in northwest China, including Xinjiang, Tibet, and other regions, are ...
Zhengwei Yin +10 more
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Cyclic di‐GMP inactivates T6SS and T4SS activity in Agrobacterium tumefaciens [PDF]
Molecular Microbiology, 2019 Summary The Type VI secretion system (T6SS) is a bacterial nanomachine that delivers effector proteins into prokaryotic and eukaryotic preys. This secretion system has emerged as a key player in regulating the microbial diversity in a population. In the plant pathogen Agrobacterium tumefaciens
Ronan R. McCarthy +5 more
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Cell Reports, 2022 Bacterial type IV secretion systems (T4SSs) are the specific devices that mediate the dissemination of antibiotic resistant genes via horizontal gene transfer (HGT). Multi-drug-resistant Enterococcus faecalis (E. faecalis) represents a clinical public health threat because of its transferable plasmid with a functional plasmid-encoded (PE)-T4SS.
Mingxi Hua +10 more
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An Anaplasma phagocytophilum T4SS effector, AteA, is essential for tick infection [PDF]
mBio, 2023 ABSTRACTPathogens must adapt to disparate environments in permissive host species, a feat that is especially pronounced for vector-borne microbes, which transition between vertebrate hosts and arthropod vectors to complete their lifecycles. Most knowledge about arthropod-vectored bacterial pathogens centers on their life in the mammalian host, where ...
Jason M. Park +8 more
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Analysis of T4SS-induced signaling by H. pylori using quantitative phosphoproteomics [PDF]
Frontiers in Microbiology, 2014 Helicobacter pylori is a Gram-negative bacterial pathogen colonizing the human stomach. Infection with H. pylori causes chronic inflammation of the gastric mucosa and may lead to peptic ulceration and/or gastric cancer. A major virulence determinant of H.
Frithjof Glowinski +4 more
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T4SS Effector Protein Prediction with Deep Learning [PDF]
Data, 2019 Extensive research has been carried out on bacterial secretion systems, as they can pass effector proteins directly into the cytoplasm of host cells. The correct prediction of type IV protein effectors secreted by T4SS is important, since they are known to play a noteworthy role in various human pathogens.
Koray Açıcı +3 more
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