Results 221 to 230 of about 11,262 (230)

Structural biology: Loading T4SS substrates

Nature Microbiology, 2017
Structural analyses of the type IV coupling protein of the Dot/Icm type IV secretion system from Legionella pneumophila reveal how this platform recruits a plethora of substrates for translocation.
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Lymphotoxin β receptor signalling executesHelicobacter pylori-driven gastric inflammation in a T4SS-dependent manner

Gut, 2016
Lymphotoxin β receptor (LTβR) signalling has been implicated in inflammation-associated tumour development in different tissues. We have analysed the role of LTβR and alternative NF-κB signalling in Helicobacter pylori-mediated gastric inflammation and pathology.We analysed several ligands and receptors of the alternative NF-κB pathway, RelB, p52 ...
Mejías-Luque, Raquel, Zöller, Jessica, Anderl, Florian, Loew-Gil, Elena, Vieth, Michael, Adler, Thure, Engler, Daniela B, Urban, Sabine, Browning, Jeffrey L, Müller, Anne, Gerhard, Markus, Heikenwalder, Mathias   +11 more
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Effects of environment regulating T4SS on virulence and adaptability of Streptococcus suis

Environmental Research
Streptococcus suis (S. suis) represents a significant bacterial pathogen, with its zoonotic transmission from infected or deceased pigs to humans posing a serious threat to public health. The type IV secretion system (T4SS), a critical virulence factor of S. suis, is tightly regulated by diverse environmental conditions.
Yamin Shen, Yue Li, Yingying Quan, Wenjie Jin, Yuxin Wang, Baobao Liu, Yang Wang   +6 more
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Apoptotic activity and sub-cellular localization of a T4SS-associated CagE-homologue in Actinobacillus actinomycetemcomitans

Microbial Pathogenesis, 2005
A potent virulence factor, cagE homologue of Actinobacillus actinomycetemcomitans, was identified via an expression cloning strategy and periodontitis-associated CD4(+)T-cells of a humanized mouse model. Through the immuno-gold labeling with transmission electron microscopy, immunofluorescent staining, in vitro co-cultures and Western blot studies, the
Yen-Tung A, Teng, Xiaoxia, Zhang
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The Helicobacter pylori Cag Pathogenicity Island Protein Cag1 is Associated with the Function of T4SS

Current Microbiology, 2016
The human pathogen Helicobacter pylori is involved in gastric diseases ranging from gastritis to gastric cancer. Virulent strains harboring the cag pathogenicity island (cag PAI) which encode a Type IV Secretion System (T4SS) can induce pro-inflammatory cytokines such as interleukin-8 and deliver their major effector proteins CagA into the gastric ...
Xiaochun, Wang, Feng, Ling, Hua, Wang, Min, Yu, Hong, Zhu, Cheng, Chen, Jingyi, Qian, Chang, Liu, Yuanyuan, Zhang, Shihe, Shao   +9 more
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The Structural Ensemble of the Conjugative F-like T4SS

2021
Nicholas Bragagnolo, Christina Rodriguez, Gerald F. Audette   +2 more
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Solving the T4SS structural mystery

Nature Reviews Microbiology, 2014
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Substrate recognition in IncF conjugative T4SS F and R1

2011
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Structural biology: solving the T4SS structural mystery.

Nature reviews. Microbiology, 2014
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A Legionella pneumophila T4SS effector protein (Ravl) triggers mitochondrial fragmentation through phosphoinositide phosphatase activity

International Journal of Biological Macromolecules
Ruiling Zhang, Meiling Zhang, Xiaoyu Li, Zhifang Lu, Chen Song, Yangchun Du, Chelsy Chesterman, Laura van Staalduinen, Youjun Wang, Hairun Pei, Zongchao Jia, Jimin Zheng   +11 more
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