Results 21 to 30 of about 11,262 (230)

Structural, Functional and Dynamic Studies of F Plasmid T4SS Proteins [PDF]

Acta Crystallographica Section A Foundations and Advances, 2014
The transfer of genetic material within a bacterial population through the process of conjugation distributes novel genetic elements for survival in unique environments. Bacterial conjugation is important to public health as the spread antibiotic resistance genes among bacteria results in multi-drug resistance.
Gerald F. Audette
openalex   +2 more sources

Subdomains of theHelicobacter pyloriCag T4SS outer membrane core complex exhibit structural independence [PDF]

Life Science Alliance
TheHelicobacter pyloriCag type IV secretion system (Cag T4SS) has an important role in the pathogenesis of gastric cancer. The Cag T4SS outer membrane core complex (OMCC) is organized into three regions: a 14-fold symmetric outer membrane cap (OMC) composed of CagY, CagX, CagT, CagM, and Cag3; a 17-fold symmetric periplasmic ring (PR) composed of CagY ...
Jacquelyn Roberts, Sirena C. Tran, Arwen E. Frick-Cheng, Kaeli N. Bryant, Chiamaka D Okoye, W. Hayes McDonald, Timothy L. Cover, Melanie D. Ohi   +7 more
openalex   +3 more sources

Comparative Analysis of T4SS Molecular Architectures

Journal of Microbiology and Biotechnology, 2023
The recently published high-resolution R388 T4SS structure provides exciting new details about the complete complex of T4SS, including the components making up the stalk and arches, numerous symmetry mismatches between regions of the complex, and an intriguing interpretation of the closed stalk and radial symmetry of the inner membrane complex, which ...
Zehra, Mishghan, Heo, Jiwon, Chung, Jeong Min, Durie, Clarissa L   +3 more
openaire   +2 more sources

Expansion of cagA Copy Number in Helicobacter pylori During Co-Infection in a Mouse Model. [PDF]

Helicobacter
ABSTRACT Introduction The virulence factor CagA is critical in mediating inflammation, and Helicobacter pylori PMSS1 dynamically modulates cagA copy number in response to host immune pressure. Co‐infection with Salmonella enterica serotype Typhimurium has been shown to heighten systemic inflammation and reduce H.
Tissera K, Ramanayake A, Kim MA, Noh EJ, Angulmaduwa S, Seo D, Cho YJ, Cha JH.   +7 more
europepmc   +2 more sources

Undercover Agents of Infection: The Stealth Strategies of T4SS-Equipped Bacterial Pathogens [PDF]

Toxins, 2021
Intracellular bacterial pathogens establish their replicative niches within membrane-encompassed compartments, called vacuoles. A subset of these bacteria uses a nanochannel called the type 4 secretion system (T4SS) to inject effector proteins that subvert the host cell machinery and drive the biogenesis of these compartments.
Arthur Bienvenu, Eric Martinez, Matteo Bonazzi   +2 more
openaire   +4 more sources

Metabolic Potential of Candidatus Saccharimonadia Including Rare Lineages in Activated Sludge. [PDF]

Environ Microbiol Rep
Candidatus Saccharimonadia is ubiquitously found in activated sludge processes, but its ecophysiological characteristics remain poorly understood. Metagenome analysis of Ca. Saccharimonadia in size‐fractionated activated sludge revealed that the epiparasitic lifestyle may extend to diverse lineages of Ca.
Kagemasa S, Kuroda K, Nakai R, Sato M, Li YY, Kubota K.   +5 more
europepmc   +2 more sources

Translocation of YopJ family effector proteins through the VirB/VirD4 T4SS of Bartonella [PDF]

Proceedings of the National Academy of Sciences
AbstractThe evolutionary conserved YopJ family comprises numerous type-III-secretion system (T3SS) effectors of diverse mammalian and plant pathogens that acetylate host proteins to dampen immune responses. Acetylation is mediated by a central acetyltransferase domain that is flanked by conserved regulatory sequences, while a non-conserved N-terminal ...
Katja Fromm, Monica Ortelli, Alexandra Boegli, Christoph Dehio   +3 more
openalex   +3 more sources

Interaction via the N terminus of the type IV secretion system (T4SS) protein VirB6 with VirB10 is required for VirB2 and VirB5 incorporation into T-pili and for T4SS function [PDF]

Journal of Biological Chemistry, 2018
Many bacterial pathogens employ multicomponent protein complexes such as type IV secretion systems (T4SSs) to transfer virulence factors into host cells. Here we studied the interaction between two essential T4SS components: the very hydrophobic inner membrane protein VirB6, which may be a component of the translocation channel, and VirB10, which links
Charline Mary, Aurélien Fouillen, Benoit Bessette, Antonio Nanci, Christian Baron   +4 more
openalex   +4 more sources

T4SS-dependent TLR5 activation by Helicobacter pylori infection [PDF]

Nature Communications, 2019
AbstractToll-like receptor TLR5 recognizes a conserved domain, termed D1, that is present in flagellins of several pathogenic bacteria but not in Helicobacter pylori. Highly virulent H. pylori strains possess a type IV secretion system (T4SS) for delivery of virulence factors into gastric epithelial cells. Here, we show that one of the H.
Pachathundikandi, Suneesh Kumar, Tegtmeyer, Nicole, Arnold, Isabelle Catherine, Lind, Judith, Neddermann, Matthias, Falkeis-Veits, Christina, Chattopadhyay, Sujay, Brönstrup, Mark, Tegge, Werner, Hong, Minsun, Sticht, Heinrich, Vieth, Michael, Müller, Anne, Backert, Steffen   +13 more
openaire   +4 more sources

Identification of Anaplasma marginale type IV secretion system effector proteins. [PDF]

PLoS ONE, 2011
Anaplasma marginale, an obligate intracellular alphaproteobacterium in the order Rickettsiales, is a tick-borne pathogen and the leading cause of anaplasmosis in cattle worldwide. Complete genome sequencing of A.
Svetlana Lockwood, Daniel E Voth, Kelly A Brayton, Paul A Beare, Wendy C Brown, Robert A Heinzen, Shira L Broschat   +6 more
doaj   +1 more source