Results 61 to 70 of about 11,262 (230)
Frontiers in Microbiology, 2019 The dispersal of mobile genetic elements and their gene cargo relies on type IV secretion systems (T4SS). In this work the ICEAfe1 Tra-type T4SS nanomachine, encoded in the publicly available genome of Acidithiobacillus ferrooxidans ATCC 23270TY, was ...
Rodrigo Flores-Ríos +9 more
doaj +1 more source
Helicobacter pylori CagL Y58/E59 mutation turns-off type IV secretion-dependent delivery of CagA into host cells. [PDF]
PLoS ONE, 2014 The type IV secretion system (T4SS) is a major virulence determinant of the gastric pathogen Helicobacter pylori. The CagL protein is a specialized adhesin of the corresponding T4SS pilus, which establishes initial contact with the integrin β1 receptor ...
Nicole Tegtmeyer +3 more
doaj +1 more source
Primary Murine Macrophages as a Tool for Virulence Factor Discovery in Coxiella burnetii
Microbiology Spectrum, 2022 Coxiella burnetii requires a type IVB secretion system (T4SS) to promote intracellular replication and virulence. We hypothesized that Coxiella employs its T4SS to secrete effectors that enable stealthy colonization of immune cells.
Elizabeth Di Russo Case +6 more
doaj +1 more source
Polar delivery of Legionella type IV secretion system substrates is essential for virulence [PDF]
, 2017 A recurrent emerging theme is the targeting of proteins to subcellular microdomains within bacterial cells, particularly to the poles. In most cases, it has been assumed that this localization is critical to the protein’s function. Legionella pneumophila
Chang, Yi-Wei +4 more
core +1 more source
How to rewire the host cell: A home improvement guide for intracellular bacteria. [PDF]
, 2017 Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate.
Cornejo, Elias +2 more
core +2 more sources
Spatiotemporal Regulation of a Legionella pneumophila T4SS Substrate by the Metaeffector SidJ
PLOS Pathogens, 2015 Modulation of host cell function is vital for intracellular pathogens to survive and replicate within host cells. Most commonly, these pathogens utilize specialized secretion systems to inject substrates (also called effector proteins) that function as toxins within host cells.
Kwang Cheol Jeong +2 more
openalex +6 more sources
Xanthomonas campestris pv. campestris (cause of black rot of crucifers) in the genomic era is still a worldwide threat to brassica crops [PDF]
, 2012 Background Xanthomonas campestris pv. campestris (Xcc) (Pammel) Dowson is a Gram-negative bacterium that causes black rot, the most important disease of vegetable brassica crops worldwide. Intensive molecular investigation of Xcc is gaining momentum and
Holub, E. B., Vicente, Joana G.
core +1 more source
Journal of Global Antimicrobial ResistanceInvasive group A streptococcal (iGAS) infections have been increasing in Europe, Australia, and the USA, but few data from China are available. This study intended to provide local data to highlight the characteristics of iGAS infections in China.A retrospective analysis was performed on clinical iGAS infection data from 2014 to 2023 in a tertiary ...
Qiong Wu +3 more
openalex +4 more sources
Spectrophotometric Assays to Quantify the Activity of T4SS ATPases
, 2019 Biogenesis of T4SS apparatus and substrate transport require energy. Conjugative T4SS have three ATPases that enable DNA processing and transport of the nucleoprotein complex to the recipient cell. In the conjugative plasmid R388, these ATPases are named TrwB, TrwK, and TrwD.
Cabezón Navarro, María Elena +1 more
openaire +4 more sources
Type IV Secretion System of Brucella spp. and its Effectors
Frontiers in Cellular and Infection Microbiology, 2015 Brucella spp. cause brucellosis in domestic and wild animals. They are intracellular bacterial pathogens and used as model organisms to study intracellular bacterial infections.
Yuehua eKe +3 more
doaj +1 more source