Legionella pneumophila strain 130b possesses a unique combination of type IV secretion systems and novel Dot/Icm secretion system effector proteins [PDF]
, 2010 Legionella pneumophila is a ubiquitous inhabitant of environmental water reservoirs. The bacteria infect a wide variety of protozoa and, after accidental inhalation, human alveolar macrophages, which can lead to severe pneumonia. The capability to thrive
Beatson, Scott A. +13 more
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Unconventional lateral gene transfer in extreme thermophilic bacteria [PDF]
, 2011 Conjugation and natural competence are two major mechanisms that explain the acquisition of foreign genes throughout bacterial evolution. In recent decades, several studies in model organisms have revealed in great detail the steps involved in such ...
Berenguer, José +5 more
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Alteration of host cell ubiquitination by the intracellular bacterial pathogen Coxiella burnetii [PDF]
, 2014 The intracellular bacterial agent of Q fever, Coxiella burnetii, replicates within a phagolysosomelike parasitophorous vacuole (PV) in human macrophages and delivers effector proteins to the host cytosol via a Dot/Icm type IV secretion system (T4SS). The
Pritchett, Lindsay, Voth, Daniel E.
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Orientia tsutsugamushi ankyrin repeat-containing protein family members are Type 1 secretion system substrates that traffic to the host cell endoplasmic reticulum [PDF]
, 2015 Scrub typhus is an understudied, potentially fatal infection that threatens one billion persons in the Asia-Pacific region. How the causative obligate intracellular bacterium, Orientia tsutsugamushi, facilitates its intracellular survival and ...
Beare, Paul A. +10 more
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The FEBS Journal, EarlyView.The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima +12 more
wiley +1 more source
The Agrobacterium VirB/VirD4 T4SS: Mechanism and Architecture Defined Through In Vivo Mutagenesis and Chimeric Systems [PDF]
, 2018 The Agrobacterium tumefaciens VirB/VirD4 translocation machine is a member of a superfamily of translocators designated as type IV secretion systems (T4SSs) that function in many species of gram-negative and gram-positive bacteria. T4SSs evolved from ancestral conjugation systems for specialized purposes relating to bacterial colonization or infection.
Yang Grace Li, Peter J. Christie
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Insights on small-molecules inhibitors and protein-protein interactions of the T4SS [PDF]
Acta Crystallographica Section A Foundations and Advances, 2014 ABSTRACT: Bacterial T4SS are complexes, constituted of 8 to 12 conserved proteins, used by many gram-negative bacteria for the translocation of proteins and DNA-protein complexes as well as for the transportation of DNA-protein complexes across their cell envelope.
Ingrid Um Nlend, Christian Baron
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The gonococcal genetic island and type IV secretion in the pathogenic Neisseria
Frontiers in Cellular and Infection Microbiology, 2011 Eighty percent of Neisseria gonorrhoeae strains and some Neisseria meningitidis strains encode a 57 kb gonococcal genetic island (GGI). The GGI was horizontally acquired and is inserted in the chromosome at the replication terminus. The GGI is flanked by
Meghan E Ramsey +2 more
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Molecular architecture of bacterial type IV secretion systems.
PLoS Pathogens, 2022 Bacterial type IV secretion systems (T4SSs) are a versatile group of nanomachines that can horizontally transfer DNA through conjugation and deliver effector proteins into a wide range of target cells.
Michael J Sheedlo +3 more
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Type three secretion system-mediated escape of Burkholderia pseudomallei into the host cytosol is critical for the activation of NFκB. [PDF]
, 2014 BackgroundBurkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease endemic in Southeast Asia and Northern Australia.
Chen, Isabelle Gek Joo +9 more
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