Results 81 to 90 of about 11,262 (230)
Microbiology and Immunology, Volume 70, Issue 1, Page 15-26, January 2026.ABSTRACT The periodontal pathogen Porphyromonas gingivalis secretes gingipains, highly hydrolytic proteases, to the cell surface or external environment via a type IX secretion system (T9SS). PorE is one of the T9SS component proteins essential for gingipain secretion. It consists of four domains: TPR, WD40, CRD, and OmpA_C‐like.
Takashi Tominaga +9 more
wiley +1 more source
A T4SS Effector Targets Host Cell Alpha-Enolase Contributing to Brucella abortus Intracellular Lifestyle [PDF]
Frontiers in Cellular and Infection Microbiology, 2016 Brucella abortus, the causative agent of bovine brucellosis, invades and replicates within cells inside a membrane-bound compartment known as the Brucella containing vacuole (BCV). After trafficking along the endocytic and secretory pathways, BCVs mature into endoplasmic reticulum-derived compartments permissive for bacterial replication. Brucella Type
Maria Inés Marchesini +4 more
openaire +4 more sources
Enterococcal PrgU Provides Additional Regulation of Pheromone-Inducible Conjugative Plasmids
mSphere, 2021 Bacteria utilize type 4 secretion systems (T4SS) to efficiently transfer DNA between donor and recipient cells, thereby spreading genes encoding antibiotic resistance as well as various virulence factors. Regulation of expression of the T4SS proteins and
Lena Lassinantti +8 more
doaj +1 more source
Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes [PDF]
, 2015 The bacterial pathogen Helicobacter pylori commonly colonizes the human gastric mucosa during early childhood and persists throughout life. The organism has evolved multiple mechanisms for evading clearance by the immune system and, despite inducing ...
Robinson, K, White, JR, Winter, JA
core +1 more source
Plant Biotechnology Journal, Volume 24, Issue 1, Page 131-144, January 2026.Summary Agroinfiltration, a method utilizing agrobacteria to transfer DNA into plant cells, is widely used for transient gene expression in plants. Besides the commonly used Agrobacterium strains, Rhizobium rhizogenes can also introduce foreign DNA into host plants for gene expression. While many R. rhizogenes strains have been known for inducing hairy
Juan Carlos Lopez‐Agudelo +11 more
wiley +1 more source
BLOC1S1 Attenuates B. Melitensis 16M LPS‐Triggered Autophagy by Spatial Confinement of TDP‐43
Advanced Science, Volume 12, Issue 45, December 4, 2025.This study explores how B. melitensis 16M LPS and BLOC1S1 regulate autophagy in goat spermatogonial stem cells. The 16M LPS is activating AMPK‐dependent autophagy, increasing LC3B‐II/I ratios and lysosomal genes, while Escherichia coli LPS shows no effect.
Shicheng Wan +13 more
wiley +1 more source
Prediction of T4SS Effector Proteins for Anaplasma phagocytophilum Using OPT4e, A New Software Tool [PDF]
Frontiers in Microbiology, 2019 Type IV secretion systems (T4SS) are used by a number of bacterial pathogens to attack the host cell. The complex protein structure of the T4SS is used to directly translocate effector proteins into host cells, often causing fatal diseases in humans and animals. Identification of effector proteins is the first step in understanding how they function to
Zhila Esna Ashari +6 more
openaire +4 more sources
Phylogeographic diversity and mosaicism of the Helicobacter pylori tfs integrative and conjugative elements. [PDF]
, 2018 Background: The genome of the gastric pathogen Helicobacter pylori is characterised by considerable variation of both gene sequence and content, much of which is contained within three large genomic islands comprising the cag pathogenicity island (cagPAI)
Croxall, Nicola J +2 more
core +4 more sources
Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms
Drug Development Research, Volume 86, Issue 8, December 2025.ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu +5 more
wiley +1 more source
Biochemical Analysis of CagE: A VirB4 Homologue of Helicobacter pylori Cag-T4SS
PLOS ONE, 2015 Helicobacter pylori are among the most successful human pathogens that harbour a distinct genomic segment called cag Pathogenicity Island (cag-PAI). This genomic segment codes for a type IV secretion system (Cag-T4SS) related to the prototypical VirB/D4 system of Agrobacterium tumefaciens (Ag), a plant pathogen. Some of the components of Cag-T4SS share
Mohd Shariq +5 more
openaire +3 more sources