Results 91 to 100 of about 469,115 (308)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Low-Floor Tanner Codes via Hamming-Node or RSCC-Node Doping
, 2006 We study the design of structured Tanner codes with low error-rate floors on the AWGN channel. The design technique involves the “doping” of standard LDPC (proto-)graphs, by which we mean Hamming or recursive systematic convolutional (RSC) code ...
Ryan, William E. +5 more
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Combining K-72 Hepatic Failure with 15 Individual T-Codes to Identify Patients with Idiosyncratic Drug-Induced Liver Injury in the Electronic Medical Record. [PDF]
Dig Dis Sci, 2022 Louissaint J +3 more
europepmc +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Structure of CSS and CSS-T quantum codes
Designs, Codes and CryptographyWe investigate CSS and CSS-T quantum error-correcting codes from the point of view of their existence, rarity, and performance. We give a lower bound on the number of pairs of linear codes that give rise to a CSS code with good correction capability, showing that such pairs are easy to produce with a randomized construction.
Berardini, Elena +2 more
openaire +2 more sources
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Urban ScienceIn this cross-sectional, ecological study of Los Angeles County ZIP codes, we evaluated the association between tree canopy coverage and asthma prevalence.
Pranav Aiyer +3 more
doaj +1 more source
Concatenated Space Time Block Codes and TCM, Turbo TCM Convolutional as well as Turbo Codes
, 2000 Space-time block codes provide substantial diversity advantages for multiple transmit antenna systems at a low decoding complexity. In this paper, we concatenate space-time codes with Convolutional Codes (CC), Turbo Convolutional codes (TC), Turbo BCH ...
Pliquett, J. +4 more
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