Results 271 to 280 of about 12,899,769 (365)

The endoplasmic reticulum stress status of CD4+ T lymphocytes and its association with mTOR-mediated autophagic-lysosomal disorder in elderly sepsis patients. [PDF]

Front Immunol
Cheng W, Zhang J, Li D, Xie Y, Lei X, Wang H, Cui N.   +6 more
europepmc   +1 more source

Stimuli‐Responsive CuFeTe2 Nanosheets for Amplified Cuproptosis/Ferroptosis in Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Dual‐stimuli‐responsive CuFeTe2 nanosheets (CFT) induce cuproptosis/ferroptosis via TME‐responsive Fe2⁺/Cu2⁺ release and NIR‐II photothermal effects, amplifying ROS and depleting HSP70/ATP to trigger ICD and immune activation, while ensuring biocompatible renal clearance for TNBC therapy.
Molin Liu, Jian Zheng, Mengqi Yu, Qirui Wang, Yi Yuan, Nannan Shao, Xiaoliang Yang, Tianxi Shen, Li Wang, Aiyun Li, Rui Liu, Jimin Cao, Xi Liu, Fangfang Cao, Yanlin Feng   +14 more
wiley   +1 more source

Effects of Mesenchymal Stem Cells on Functions of Chimeric Antigen Receptor-Expressing T Lymphocytes and Natural Killer Cells. [PDF]

Cells
Volarevic V, Harrell CR, Arsenijevic A, Djonov V, Volarevic A.   +4 more
europepmc   +1 more source

Identifying Tipping Points during Healthy Brain Aging through Single‐Nucleus Transcriptomic Analysis

Advanced Science, EarlyView.
This study applies single‐nucleus transcriptomics and systems dynamics to uncover nonlinear aging patterns in healthy human brains. By introducing dynamic network biomarker theory, the authors identify a critical tipping point at ages 56–60 during aging, and highlight glial instability as a key mediator.
Peiru Wu, Xuyu Zhao, Zixin Chen, Jingying Huang, Tengteng Dai, Jianxin Zhou, Luyao Xiao, Luonan Chen, Robert Chunhua Zhao, Jiao Wang   +9 more
wiley   +1 more source

Light-induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo. [PDF]

Nucleic Acids Res
Pulgarin DV, Pelo N, Ferrandiz L, Tršelič T, Nyberg WA, Bowlin G, Espinosa A.   +6 more
europepmc   +1 more source

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan, Xin Qin, Li Gong, Haining Liu, Bo Cheng, Jing Wang, Yajie Hu, Lingxing Zeng, Yiping Wang, Qingxu Song, Yufeng Cheng   +10 more
wiley   +1 more source

Microneurotrophin BNN27 Exerts Significant Anti-Inflammatory Effects on Murine T-Lymphocytes Following CFA-Induced Inflammatory Pain. [PDF]

Int J Mol Sci
Poulaki S, Kalantidou A, Lapi I, Gravanis A, Venihaki M.   +4 more
europepmc   +1 more source

Adoptive JC Virus-Specific T Lymphocytes for the Treatment of Progressive Multifocal Leukoencephalopathy: Experience from Two Italian Centers. [PDF]

Viruses
Pocora MM, Bini P, Berzero G, Vegezzi E, Diamanti L, Gastaldi M, Cinque P, Catalano G, Paoletti M, Pichiecchio A, Tartara F, Basso S, Baldanti F, Furione M, Comoli P, Marchioni E.   +15 more
europepmc   +1 more source

CRMP2 phosphorylation regulates polarization and spinal infiltration of CD4 + T lymphocytes, inhibits spinal glial activation, and arthritic pain. [PDF]

Pain
Jiang YP, Wen JJ, Ma X, Yuan CR, Zhou F, Zheng MJ, Tang X, Yu XK, Lai WD, Zhou YH, Yu WH, You WT, Jin Y, Park KD, Khanna R, Wen CP, Yu J.   +16 more
europepmc   +1 more source

CD103⁺CD8⁺ tissue-resident memory T lymphocytes of melanoma boost anti-tumour immunity and predict immunotherapy outcomes. [PDF]

Clin Transl Med
Zhang T, Song J, Li Y, Shen K, Xuan J, Gao Y, Lu L, Pang Z, Wang L, Yang Y, Gao Z, Hu Q, Zhu Y, Wei C, Zheng S, Luo R, Hou Y, Zhou Y, Wei C, Gu J.   +19 more
europepmc   +1 more source