Results 1 to 10 of about 717,341 (333)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Stability of Extemporaneously Prepared Rufinamide Oral Suspensions [PDF]
, 2010 Background: Rufinamide is an oral antiepileptic drug indicated for adjunctive therapy in treating generalized seizures associated with Lennox-Gastaut syndrome. Currently, rufinanide is available as 200-mg and 400-mg tablets. A liquid dosage form does not
Best, Robert +3 more
core +2 more sources
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
Improving Learning Outcomes: The iPad and Preschool Children with Disabilities
Frontiers in Psychology, 2017 The digital age has reached early childhood, and the use of touch screens by young children is common place. Research on the use of touch screen tablets with young children is becoming more prevalent; however, less information is available on the use of ...
Linda Chmiliar
doaj +1 more source
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2023 The aim of the work is to develop the industrial technology of tablets with cardioprotective action based on the domestic raw material of cultivated parsnip herb thick extract (CPHTE). Materials and methods.
N. А. Symonenko +2 more
doaj +1 more source
Development of a dissolution method for lumefantrine and artemether in immediate release fixed dose artemether/lumefantrine tablets [PDF]
, 2020 Background:Dissolution of artemether (ART ) and lumefantrine (LUM) active pharmaceutical ingredients (APIs) in fixed dose combination (FDC) ART/LUM tablets is one of the critical quality attributes.
De Spiegeleer, Bart +6 more
core +1 more source
The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise
FEBS Open Bio, EarlyView.Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji +3 more
wiley +1 more source
Image and interpretation using artificial intelligence to read ancient Roman texts [PDF]
, 2005 The ink and stylus tablets discovered at the Roman Fort of Vindolanda are a unique resource for scholars of ancient history. However, the stylus tablets have proved particularly difficult to read.
Robertson, P, Terras, M
core
Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies
FEBS Open Bio, EarlyView.Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa +13 more
wiley +1 more source
Tecnología, Ciencia y Educación, 2021 Este trabajo se hace eco de un animado debate, que está presente en los últimos años en el ámbito de la educación superior, sobre si hay que permitir o se debe prohibir el uso de dispositivos móviles por los estudiantes en el aula. A fin de facilitar una
Ana Belén Alonso-Conde +2 more
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