Results 131 to 140 of about 30,544 (319)
Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology
Advanced Science, EarlyView.This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou +14 more
wiley +1 more source
An Educational Intervention for Nurses Administering Medications : Focus on Dysphagia Patients [PDF]
, 2012 The purpose of our final project was to explore the influence of an educational intervention provided by a pharmacist to the knowledge and skills of nurses administering medications to neurological dysphagia patients.
Mantere, Anna, Oksanen, Aino-Maria
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Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA
Advanced Science, EarlyView.Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin +9 more
wiley +1 more source
Development And Evaluation Of Prolonged Release Ketoprofen Tablets [PDF]
, 2006 Suatu sistem perlepasan terpanjang telah dibangunkan menggunakan salutan filem sebagai sistem perlepasan terpanjang drug dan ketoprofen telah digunakan sebagai drug model.
Masoud Eid, Ahmad Mustafa
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Advanced Science, EarlyView.A new tissue sampling device using an acupuncture needle with bio‐compatible extraction sorbents in the recessed section is developed. The coating material using self‐wettable particles doesn't require solvent activation after sterilization. This device is applied for the anti‐cancer drug concentration monitoring during the in vivo lung perfusion ...
Runshan Will Jiang +9 more
wiley +1 more source
Emerging Nanotechnology Strategies for Obesity Therapy
Advanced Science, EarlyView.Three types of nanomaterials used for obesity treatment are highlighted, including inorganic nanomaterials, organic nanomaterials and biomimetic nanomaterials. A detailed and comprehensive introduction to the recent nanotechnology strategies for obesity management is also provided, including drug delivery, photodynamic therapy, hyperthermia, gas ...
Weili Chang +5 more
wiley +1 more source
Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis
Advanced Science, EarlyView.Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu +17 more
wiley +1 more source
COMPARISON OF ENTERIC-COATED ASPIRIN TABLETS BY DIFFERENT PRODUCERS: DISSOLUTION TEST RESULTS
Российский кардиологический журнал, 2010 .
V. V. Rafalsky +4 more
doaj
Advanced Science, EarlyView.This study developes a universal colorimetric ICA platform that integrates broad‐spectrum recognition by 4‐mercaptophenylboronic acid with dual signal enhancement—both colorimetric and catalytic—mediated by a biomimetic magnetic nanozyme. This platform, for the first time, enables simple, convenient, ultrasensitive, and simultaneous screening of ...
Qing Yu +7 more
wiley +1 more source
Effect of scientific principles of gavage feeding in oral medicine administration on knowledge and function of nurses in intensive care unit (ICU) [PDF]
, 2016 Medication through an enteral feeding tube is one of the main cares in patients hospitalized in the intensive care unit continuously being a challenge. Correct delivery of medication through an enteral feeding tube requires specific knowledge and skills ...
Ghahfarrokhi, S.S. +3 more
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