Results 81 to 90 of about 961,050 (380)
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Swedish preschool teachers’ experiences from pedagogical use of digital play
Journal of Early Childhood Education Research, 2020 This article reports on findings from an interview study with eleven Swedish preschool teachers. The purpose was to increase the knowledge about preschool teachers’ experiences from pedagogical use of digital play.
Leif Marklund
doaj
Pharmaceutics, 2020 Background: Intestinal nematode infections are usually treated with benzimidazole drugs, but the emergence of resistance to these drugs has led to an increasing demand of new anthelmintic strategies.
Ines Perez-Roman +4 more
doaj +1 more source
Разработка и регистрация лекарственных средств, 2023 Introduction. Cytochromes P450 depression is the reason for the low effectiveness of etiotropic and pathogenetic therapy of hepatitis. Recent experimental and clinical studies demonstrated the need for use of inducers of hepatocytes monooxygenase system ...
A. I. Petrakov +5 more
doaj +1 more source
Image and interpretation using artificial intelligence to read ancient Roman texts [PDF]
, 2005 The ink and stylus tablets discovered at the Roman Fort of Vindolanda are a unique resource for scholars of ancient history. However, the stylus tablets have proved particularly difficult to read.
Robertson, P, Terras, M
core
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Cuneiform Tablet Collection - Accession 1382 [PDF]
, 2018 The Cuneiform Tablet Collection consists of six cuneiform tablets ranging from 2300-547 BC. Cuneiform is the oldest known form of writing and was commonly used in the Middle East between 3,200 BC and the second century AD.
Cuneiform Tablets
core +1 more source
Stability of Extemporaneously Prepared Rufinamide Oral Suspensions [PDF]
, 2010 Background: Rufinamide is an oral antiepileptic drug indicated for adjunctive therapy in treating generalized seizures associated with Lennox-Gastaut syndrome. Currently, rufinanide is available as 200-mg and 400-mg tablets. A liquid dosage form does not
Best, Robert +3 more
core +2 more sources
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source