Results 61 to 70 of about 212,331 (265)

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau   +11 more
wiley   +1 more source

ORODISPERSIBLE TABLETS – A NOVEL APPROACH

open access: yesGomal Journal of Medical Sciences, 2017
Pharmaceutical technologists have developed a novel oral dosage forms known as orally disintegrating tablets or fast disintegrating tablets or mouth melting tablets or mouth dissolving tablets which disintegrate rapidly in saliva, usually in a matter of ...
Sattar Bakhsh Awan
doaj  

An Emerging Formulation Tablet in Tablet: An Overview

open access: yes, 2023
In recent years, the Pharmaceutical industry has witnessed remarkable advancements in drug delivery technologies, a trend expected to continue. Among the various dosage forms, tablets remain one of the most preferred options due to their practicality, ease of administration, and patient compliance.
Sangeeta Saraswat   +3 more
openaire   +3 more sources

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong   +10 more
wiley   +1 more source

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi   +6 more
wiley   +1 more source

Stability Assessment of Resveratrol Tablets Stored under Stress Conditions via Directional-Hemispherical Reflectance

open access: yesProceedings
Resveratrol is a natural polyphenol found in many vegetables and fruits [...]
Beata Szulc-Musioł, Beata Sarecka-Hujar
doaj   +1 more source

Material Considerations for Fused-Filament Fabrication of Solid Dosage Forms

open access: yesPharmaceutics, 2018
Material choice is a fundamental consideration when it comes to designing a solid dosage form. The matrix material will ultimately determine the rate of drug release since the physical properties (solubility, viscosity, and more) of the material control ...
Evert Fuenmayor   +6 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

IoT/Sensor-Based Infrastructures Promoting a Sense of Home, Independent Living, Comfort and Wellness

open access: yesSensors, 2019
This paper presents the results of three interrelated studies concerning the specification and implementation of ambient assisted living (AAL)/Internet of Things (IoT)/sensor-based infrastructures, to support resident wellness and person-centered care ...
Joan Cahill   +5 more
doaj   +1 more source

Differential Item Functioning on the Patient Health Questionnaire 8 by Disease Subtype, Language, Sex, and Age Among People With Systemic Sclerosis: A Scleroderma Patient‐Centered Intervention Network Cohort Study

open access: yesArthritis Care &Research, EarlyView.
Objective Somatic items used in depression assessments can potentially overlap with symptoms related to physical illness, including systemic sclerosis (SSc). No studies have looked at whether somatic depression items may be influenced by diffuse versus limited SSc disease subtypes, which are associated with varying degrees of symptom presentation.
Sophie Hu   +110 more
wiley   +1 more source

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