Results 51 to 60 of about 690,699 (300)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Trauma and acute care surgeons report prescribing less opioids over time. [PDF]
, 2019 IntroductionConfronted with the opioid epidemic, surgeons must play a larger role to reduce risk of opioid abuse while managing acute pain. Having a better understanding of the beliefs and practices of trauma and acute care surgeons regarding discharge ...
Anderson, Jamie E +2 more
core +2 more sources
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Tecnología, Ciencia y Educación, 2021 Esta propuesta de investigación tiene como principal objetivo profundizar en la repercusión que tiene el uso de las tablets como herramienta en el aprendizaje del alumnado desde la perspectiva docente y familiar del centro concertado Vivaldi.
Lara Alcántara González +3 more
doaj +1 more source
Photometric compliance of tablet screens and retro-illuminated acuity charts as visual acuity measurement devices [PDF]
, 2016 Mobile technology is increasingly used to measure visual acuity. Standards for chart-based acuity tests specify photometric requirements for luminance, optotype contrast and luminance uniformity.
Bastawrous, A. +5 more
core +5 more sources
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Niniveh and Alexandria: The Two Vanished Libraries of Antiquity
Revista Română de Biblioteconomie și Știința Informării, 2017 Humankind has dramatically evolved for the past thousands of years in terms of communication - starting from signs and signals conveyed via visual and auditory means and ending up with the set of signs that came to be known as the alphabet over a vast ...
Mariana Borcoman
doaj +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Towards a reading of the Vindolanda Stylus Tablets: Engineers and the Papyrologist [PDF]
, 2000 We introduce a collaborative project between the Department of Engineering Science and the Centre for the Study of Ancient Documents at the University of Oxford regarding the analysis and reading of the Vindolanda Stylus Tablets.
Terras, M
core
Unbreakable codes in electrospun fibers : digitally encoded polymers to stop medicine counterfeiting [PDF]
, 2010 Fluorescent polymer solutions can easily be electrospun into micrometer-sized fibers and subsequently encoded with long lasting digital codes by a photobleaching process.
Braeckmans, Kevin +9 more
core +2 more sources