Results 141 to 150 of about 123,486 (200)

Autoimmunity in MASLD: Focus on autoantibodies, anti‐apolipoprotein A1 IgG and G protein‐coupled receptors

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano   +3 more
wiley   +1 more source

Help can harm: Unintended consequences of child protection and parenting support for Vietnamese immigrant families in Germany

open access: yesEthos, EarlyView.
Abstract In this paper, we explore the unintended consequences of parenting support and child protection services for families who have migrated from Vietnam to Berlin, Germany. We identify such negative consequences on three levels: The relationship between practitioners and parents was, contrary to good intentions, often characterized by tensions and
Nga Thi Thanh Mai, Gabriel Scheidecker
wiley   +1 more source

The Economic Consequences of Social Unrest: Evidence from Initial Public Offerings

open access: yesEuropean Financial Management, EarlyView.
ABSTRACT Prior research attributes negative stock market performance following episodes of social unrest to elevated uncertainty. However, social unrest does not solely increase uncertainty but separately acts to decrease investor sentiment. To determine which effect dominates, we study initial public offering (IPO) underpricing, which responds ...
Philip Barrett   +2 more
wiley   +1 more source

Fatty‐acid amide hydrolase inhibition mitigates Alzheimer's disease progression in mouse models of amyloidosis

open access: yesThe FEBS Journal, EarlyView.
Enhancing endocannabinoid signaling by targeting FAAH effectively mitigates cognitive deficits, reduces amyloid pathology, and modulates neuroinflammatory responses in a preclinical model of Alzheimer's disease. This effect is potentially mediated by attenuating the Aβ‐induced overexpression of the Bace1 gene through CB1‐dependent hypermethylation of ...
Sergio Oddi   +12 more
wiley   +1 more source

SNP and Structural Study of the Notch Superfamily Provides Insights and Novel Pharmacological Targets against the CADASIL Syndrome and Neurodegenerative Diseases. [PDF]

open access: yesGenes (Basel)
Papageorgiou L   +12 more
europepmc   +1 more source

A steric gate prevents mutagenic dATP incorporation opposite 8‐oxo‐deoxyguanosine in mitochondrial DNA polymerases

open access: yesThe FEBS Journal, EarlyView.
Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres   +10 more
wiley   +1 more source

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