Results 141 to 150 of about 14,793,566 (190)

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Cancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen Wise, Nadege Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len R. Stephens, Kate G. Storey, Doreen A. Cantrell, Bart Vanhaesebroeck, Nicholas R. Leslie   +16 more
wiley   +1 more source

Outcomes of Kidney Transplants From Standard Criteria Donors With Diabetes: A Propensity Score-Matched Study. [PDF]

Kidney Med
Pepato PH, Colella M, Foresto RD, Tedesco-Silva H, Pestana JM, Requião-Moura L.   +5 more
europepmc   +1 more source

Early Visual Development in Albinism

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Visual system development is incomplete at birth, and while fixation and tracking usually emerge within the first weeks of life, some infants show delayed visual development (DVDev). This is frequently observed in infants with albinism, yet the timing of visual attentiveness and subsequent visual acuity development remains unclear ...
Catelijne Maria Neijzen, Ymkje Marije Hettinga, Herman Eduard Talsma, Charlotte Corinne Kruijt, Joke Helena de Boer, Gerard Cornelis de Wit, Maria Michielde van Genderen   +6 more
wiley   +1 more source

Metabolomics Analysis Uncovers Distinct Profiles of Liver Post-Transplant Patients by Immunosuppression Regimen. [PDF]

Metabolites
Baciu C, Hasjim BJ, Maleki S, Pasini E, Patel MK, Shojaee M, Azhie A, Saracino G, Asrani SK, Bhat M.   +9 more
europepmc   +1 more source

Combined Liver-Kidney Transplantation in Pediatric Patients From Colombia: A Case Series. [PDF]

Pediatr Transplant
Padilla-Guzmán A, Ortega-Gamboa SA, Forero-Delgadillo JM, Ochoa-Jiménez VA, Portilla-Buenaventura AM, Mateus CJC, Botero-Osorio V, Pachajoa H, Restrepo JM.   +8 more
europepmc   +1 more source

Squamoid Eccrine Ductal Carcinoma: Case Series of a Rare, Potentially Aggressive Skin Cancer Associated With Immunosuppression

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Squamoid Eccrine Ductal Carcinoma (SEDC) is a rare cutaneous adenexal carcinoma first described in 1997. It has distinct biphasic features on histology which commonly result in misdiagnosis as Bowen disease or cutaneous squamous cell carcinomas (cSCC) if diagnostic skin biopsies are too superficial. This may lead to a delay in diagnosis. It is
Xiang Li Tan, Pooja Patel, Jeva Cernova, Sarah Hogan, Jason Thomson, Efthymios Hadjimichael, Sharanpal Jeetle, Dorota Markiewicz, Michael Sheaff, Nilukshi Wijesuriya, Mark Hawthorne, Graeme Moir, Matthew Stodell, Kapil Bhargava, Suchitra Chinthapalli, Catherine A. Harwood   +15 more
wiley   +1 more source

Genetic and environmental aetiologies of the transition from nonsuicidal self-injury to suicide attempt: a longitudinal twin study. [PDF]

Mol Psychiatry
Ohlis A, Li L, Kuja-Halkola R, Lundström S, D'Onofrio BM, Hellner C, Lichtenstein P, Cederlöf M, Chang Z, Bjureberg J.   +9 more
europepmc   +1 more source

A DPP6‐Targeted PET Tracer for Non‐Invasive Imaging of Transplanted Human Islets

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Dipeptidyl peptidase‐like protein 6 (DPP6) is a potential molecular imaging biomarker for pancreatic and transplanted islets of Langerhans. 4hD29 is a single‐domain antibody with nanomolar affinity for DPP6. Here, we demonstrate the generation and validation of [68Ga]Ga‐NOTA‐4hD29 for Positron Emission Tomography (PET) imaging of ...
Amina Khalil, Arturo Roca‐Rivada, Svitlana Vasylovska, Lorenzo J. I. Balestri, Irina Velikyan, Sayro Jawurek, Alexandra C. Title, Burcak Yesildag, Luke R. Odell, Joey Lau, Decio L. Eizirik, Olof Eriksson   +11 more
wiley   +1 more source

Efficacy and safety of bupleurum-containing formulas combined with chemotherapy for triple-negative breast cancer: a systematic review and meta-analysis. [PDF]

Front Oncol
Li S, Chen J, Ke L, Leng Y, Cui G, He Q, Chen H, Jiang P, Luo L.   +8 more
europepmc   +1 more source

Diagnosis and Management of Adult Type 1 Diabetes Mellitus: Systematic Reviews of Biomarkers, Insulin Regimens and Insulin Delivery Devices Highlighting Evidence Gaps in Emergency and Humanitarian Settings

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Supporting the World Health Organization's (WHO) 2021 Global Diabetes Compact's goals, we conducted three systematic reviews on type 1 diabetes (T1D) in adults concerning (1) diagnostic biomarkers, (2) insulin regimens and (3) insulin delivery devices, focusing on emergency and humanitarian settings.
Niyati Patwa, Alexandria Bennett, Nicole Shaver, Lama Dahroug, Becky Skidmore, Shannon E. Kelly, George Wells, Andrea C. Tricco, Heather Lochnan, Julian Little, Melissa Brouwers   +10 more
wiley   +1 more source