Results 41 to 50 of about 3,759 (252)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Acquisition and Formalization of Tacit Knowledge for Value Chain Generation in Local Production Networks

, 2023
Interest in producing goods locally again has risen. This leads to new challenges for companies producing locally, especially since they are mostly small enterprises and do not always have resources to adapt Industry 4.0 technologies. Therefore, collaborating in networks can strengthen local production.
Matthias Kerzel, Julia Markert, Emad Aghajanzadeh, Stephanie von Riegen, Lothar Hotz, Pascal Krenz   +5 more
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Knowledge Phenomenology Research on Disruptive Innovative Design of Future Industries [PDF]

中国工程科学
Innovative design serves as both a precursor and a foundational component in advancing future industries. It is also a key driver in fostering new quality productive forces.
Jiang Xu, Haoxiang Qu
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Types of Knowledge Transferred Within International Interfirm Alliances in the Nigerian Oil Industry and the Potential to Develop Partners’ Innovation Capacity

Administrative Sciences
This study focuses on exploring the nature of inter-organizational learning and the types of knowledge that are transferred/shared between foreign multinational companies (MNCs) and their local partner firms within international interfirm alliances in ...
Okechukwu C. Okonkwo
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Model Knowledge Management di Perpustakaan Universitas Padjadjaran

Lentera Pustaka: Jurnal Kajian Ilmu Perpustakaan, Informasi dan Kearsipan, 2020
Knowledge Management mempunyai peran yang semakin penting dalam organisasi di berbagai industri. Melalui Knowledge Management, organisasi berusaha untuk memperoleh atau menciptakan pengetahuan yang berpotensi, bermanfaat dan membuatnya tersedia bagi ...
Eko Retno Wulandari, Risa Nurisani
doaj   +1 more source

Tacit Knowledge for Military Leadership: Seeking Insight into the Acquisition and Use of Practical Knowledge [PDF]

, 2000
Abstract : The goal of the project was to provide preliminary insight into the process of tacit knowledge acquisition and to support the development of tools to assess the use of various knowledge-acquisition processes in solving practical leadership problems. These requirements were met by (a) reviewing relevant theory and research on tacit knowledge,
Joseph Psotka, Robert J. Sternberg, Jennifer Hedlund   +2 more
openaire   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source