Results 131 to 140 of about 11,965 (161)

New-Onset Diabetes After Transplantation in Renal Recipients: A Pilot Comparative Study of Immediate vs. Extended-Release Tacrolimus Formulation. [PDF]

Pharmaceuticals (Basel)
Ratiu IA, Bănică F, Moisa C, Pașca B, Gîtea D, Grosu ID, Bako GC, Voștinaru O, Abu Dayyih W, Filip L.   +9 more
europepmc   +1 more source

Glutathione Peroxidase from <i>Talaromyces marneffei</i> Interacts with Host Cytoskeletal Proteins: Insights from Yeast Two-Hybrid and Molecular Dynamics Simulations. [PDF]

Int J Mol Sci
Wangsanut T, Aung YHH, Oo YHH, Lawan N, Pongpom M.   +4 more
europepmc   +1 more source

Characterisation of the human renal tight junction barrier and the influence of TGF?1 and cyclosporine A

, 2011
Kirk, Adam
core  

Equilibrium studies of a fluorescent tacrolimus binding to surfactant protein A

Analytical Biochemistry, 2005
Tacrolimus (FK506) is a hydrophobic immunosuppressive agent used in kidney, liver, and lung transplantation. The objective of this study was to characterize the binding of FK506 to surfactant protein A (SP-A), an abundant lipoprotein found in the alveolar fluid that functions as part of the innate immune system in the lung.
Olga Cañadas, Alejandra Saenz, Guillermo Orellana   +2 more
exaly   +4 more sources

Binding of Pimecrolimus and Tacrolimus to Skin and Plasma Proteins: Implications for Systemic Exposure after Topical Application

Drug Metabolism and Disposition, 2008
Pimecrolimus and tacrolimus are calcineurin inhibitors used for the topical treatment of atopic dermatitis. Although structurally similar, they display specific differences including higher lipophilicity and lower skin permeation of pimecrolimus. The aim of the present study was to understand the reason for the differences in skin permeation; in ...
H Markus Weiss, Anton Stuetz, Andreas Billich   +2 more
exaly   +4 more sources

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Role of FK506 Binding Protein on Tacrolimus Distribution in Red Blood Cells

Pharmaceutical Research, 2020
Tacrolimus is distributed mainly in red blood cells (RBCs) after transfer into blood. This study aimed to evaluate the effect of FK506-binding proteins (FKBPs) on RBC distribution of tacrolimus in a physiological environment.Human RBCs were isolated from fresh blood samples from healthy volunteers.
Naoki Yoshikawa, Ayako Matsuo, Nobuhiro Matsumoto   +2 more
exaly   +3 more sources

Validation of methods to study the distribution and protein binding of tacrolimus in human blood

Journal of Pharmacological and Toxicological Methods, 2001
Tacrolimus is a macrolide immunosuppressant that has a narrow therapeutic index, displays considerable variability in response, and has the potential for serious drug interactions. Therapeutic drug monitoring and dose individualisation for tacrolimus is complicated but essential.
K F Brown, Andrew J Mclachlan
exaly   +3 more sources