Results 121 to 130 of about 78,568 (253)

DELirium treatment with Transcranial Electrical Stimulation (DELTES): study protocol for a multicentre, randomised, double-blind, sham-controlled trial

BMJ Open
Introduction Delirium, a clinical manifestation of acute encephalopathy, is associated with extended hospitalisation, long-term cognitive dysfunction, increased mortality and high healthcare costs.
Arjen J C Slooter, Marielle H Emmelot-Vonk, Julia van der A, Yorben Lodema, Thomas H Ottens, Dennis J L G Schutter, Willem de Haan, Edwin van Dellen, Indira Tendolkar   +8 more
doaj   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Curriculum alignment with international graduate attribute standards in engineering education: The CPUT experience

The Curriculum Journal, EarlyView.
Abstract This paper presents a qualitative case study of how the Mechanical Engineering Diploma programme at Cape Peninsula University of Technology (CPUT) systematically aligned its curriculum with both national and international graduate attribute (GA) standards.
Ali Rugbani, Simphiwe Nqabisa
wiley   +1 more source

Integration bile acid metabolomics and gut microbiome to study the anti-liver fibrosis effects of total alkaloids of Corydalis saxicola Bunting

Chinese Medicine
Background Bile acids and gut microbiota participate in the pathogenesis of liver fibrosis (LF). The total alkaloids of Corydalis saxicola Bunting (TACS) is a traditional Chinese medicine extract that has been used to treat LF, but the underlying ...
Qianyi Wang, MeiLing Zhang, Mingwei Meng, Zhuo Luo, Ziping Pan, Lijun Deng, Jinghua Qin, Bingjian Guo, Dan Zhu, Yanmin Zhang, Hongwei Guo, Yonghong Liang, Zhiheng Su   +12 more
doaj   +1 more source

Mechanistic insights into cortical network entrainment by tACS and tDCS: A computational modeling approach

Brain Research Bulletin
Non-invasive brain stimulation techniques such as transcranial alternating current stimulation (tACS) and transcranial direct current stimulation (tDCS) are increasingly explored for modulating large-scale brain oscillations associated with cognition ...
Sandeep Kumar Agnihotri, Jiang Cai
doaj   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Individualized frequency and montage tACS to engage theta-gamma coupling and enhance working memory in mild cognitive impairment

Frontiers in Psychiatry
Mild Cognitive Impairment (MCI) is a clinical prodromal stage of Alzheimer’s disease. Enhancing executive functions in patients with MCI could optimize cognitive compensatory mechanisms and slow cognitive decline.
Mina Mirjalili, Mina Mirjalili, Iryna S. Palamarchuk, Iryna S. Palamarchuk, Heather Brooks, Heather Brooks, Reza Zomorrodi, Reza Zomorrodi, Ashley Melichercik, Wei Wang, Wei Wang, Sean M. Nestor, Sean M. Nestor, Daniel M. Blumberger, Daniel M. Blumberger, Daniel M. Blumberger, Abhishek Datta, Christopher Bowie, Christopher Bowie, Bernadette Mdawar, Bernadette Mdawar, Kullervo Hynynen, Kullervo Hynynen, Sanjeev Kumar, Sanjeev Kumar, Sanjeev Kumar, Sanjeev Kumar, Tarek K. Rajji, Tarek K. Rajji, Tarek K. Rajji, Tarek K. Rajji   +30 more
doaj   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

Ocean Governance and Marine Conservation: Institutional Work as a Lever for Ocean Sustainability

Environmental Policy and Governance, EarlyView.
ABSTRACT Ocean governance presents one of the most complex environmental policy challenges of our time, requiring coordinated action across multiple scales, sectors and stakeholder groups. This paper applies institutional work theory to systematically examine how actors create, maintain and disrupt the governance arrangements underpinning ocean ...
Kedar Uttam, Kristjan Jespersen, Paige Olmsted, Katryn Pasaribu   +3 more
wiley   +1 more source

Efficacy of High-Definition Transcranial Alternating Current Stimulation (HD-tACS) at the M1 Hotspot Versus C3 Site in Modulating Corticospinal Tract Excitability

Biomedicines
Previous studies have shown that beta-band transcranial alternating current stimulation (tACS) applied at the M1 hotspot can modulate corticospinal excitability.
Hao Meng, Michael Houston, Nicholas Dias, Chen Guo, Gerard Francisco, Yingchun Zhang, Sheng Li   +6 more
doaj   +1 more source