Nitric Oxide Signals Through IRAG to Inhibit TRPM4 Channels and Dilate Cerebral Arteries
Function, 2021 Nitric oxide (NO) relaxes vascular smooth muscle cells (SMCs) and dilates blood vessels by increasing intracellular levels of cyclic guanosine monophosphate (cGMP), which stimulates the activity of cGMP-dependent protein kinase (PKG).
Sher Ali +6 more
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Macroglobulin signaling system [PDF]
Biomeditsinskaya Khimiya, 2012 This review will focus on the systematization of knowledge about structure of macroglobulin signaling system, which includes macroglobulin family proteins (alpha-2-macroglobulin, alpha-2-glycoprotein, pregnancy associated plasma protein A), their receptors (LRP, grp78), ligands (proteinases, cytokines, hormones, lipids, et al.) transforming and ...
N A, Zorin, V N, Zorina
openaire +2 more sources
STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells
eLife, 2022 Peripheral coupling between the sarcoplasmic reticulum (SR) and plasma membrane (PM) forms signaling complexes that regulate the membrane potential and contractility of vascular smooth muscle cells (VSMCs).
Vivek Krishnan +9 more
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Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function
Cells, 2021 TRPA1 (transient receptor potential ankyrin 1), the lone member of the mammalian ankyrin TRP subfamily, is a Ca2+-permeable, non-selective cation channel.
Michael G. Alvarado +2 more
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Endothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension
Frontiers in Molecular Biosciences, 2023 Introduction: Hypoxia-induced dilation of cerebral arteries orchestrated by Ca2+-permeable transient receptor potential ankyrin 1 (TRPA1) cation channels on endothelial cells is neuroprotective during ischemic stroke, but it is unknown if the channel has
Michelle N. Sullivan +7 more
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Cell Reports, 2022 Summary: Biologically active small molecules can impart modulatory effects, in some cases providing extended long-term memory. In a screen of biologically active small molecules for regulators of tumor necrosis factor (TNF) induction, we identify several
Sinu P. John +13 more
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Performance Evaluation of Signaling in the IP QoS System
Journal of Telecommunications and Information Technology, 2023 The IP QoS System is based on next generation networks (NGN) and differentiated services (DiffServ) architectures. Its main part is a signaling system, which allows to send a request from a user to the system for establishing new connection with ...
Halina Tarasiuk +3 more
doaj +1 more source
DNA-based artificial molecular signaling system that mimics basic elements of reception and response
Nature Communications, 2020 In order to maintain tissue homeostasis, cells communicate with the outside environment by receiving molecular signals, transmitting them, and responding accordingly with signaling pathways.
Ruizi Peng +10 more
semanticscholar +1 more source
From data towards knowledge: Revealing the architecture of signaling systems by unifying knowledge mining and data mining of systematic perturbation data [PDF]
, 2013 Genetic and pharmacological perturbation experiments, such as deleting a gene and monitoring gene expression responses, are powerful tools for studying cellular signal transduction pathways.
Cowart, Ashley +3 more
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On Local Testability in the Non-Signaling Setting [PDF]
, 2020 Non-signaling strategies are a generalization of quantum strategies that have been studied in physics for decades, and have recently found applications in theoretical computer science.
Chiesa, Alessandro +2 more
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