Results 21 to 30 of about 31,177,116 (343)
Molecular Mechanisms of Kidney Injury and Repair in Arterial Hypertension [PDF]
, 2019 The global burden of chronic kidney disease is rising. The etiologies, heterogeneous, and arterial hypertension, are key factors contributing to the development and progression of chronic kidney disease. Arterial hypertension is induced and maintained by
Eckardt, Kai-Uwe +1 more
core +2 more sources
Acetylcholine signaling system in progression of lung cancers
Pharmacology and Therapeutics, 2019 The neurotransmitter acetylcholine (ACh) acts as an autocrine growth factor for human lung cancer. Several lines of evidence show that lung cancer cells express all of the proteins required for the uptake of choline (choline transporter 1, choline ...
J. Friedman +9 more
semanticscholar +1 more source
Purinergic signalling in systemic sclerosis
Rheumatology, 2021 Abstract SSc is a chronic autoimmune rheumatic disease that involves numerous organs and presents major management challenges. The histopathologic hallmarks of SSc include vasculopathy, fibrosis and autoimmune phenomena involving both innate and adaptive immune systems.
Höppner, Jakob +6 more
openaire +2 more sources
CD47‐signal regulatory protein α signaling system and its application to cancer immunotherapy
Cancer Science, 2018 Tumor cells evade immune surveillance through direct or indirect interactions with various types of immune cell, with much recent attention being focused on modifying immune cell responses as the basis for the development of new cancer treatments. Signal
Yoji Murata +3 more
semanticscholar +1 more source
A Study of the PDGF Signaling Pathway with PRISM [PDF]
, 2011 In this paper, we apply the probabilistic model checker PRISM to the analysis of a biological system -- the Platelet-Derived Growth Factor (PDGF) signaling pathway, demonstrating in detail how this pathway can be analyzed in PRISM.
A. Aziz +44 more
core +3 more sources
Systems theory of Smad signalling [PDF]
IEE Proceedings - Systems Biology, 2006 Transforming Growth Factor-beta (TGF-beta) signalling is an important regulator of cellular growth and differentiation. The principal intracellular mediators of TGF-beta signalling are the Smad proteins, which upon TGF-beta stimulation accumulate in the nucleus and regulate transcription of target genes.
Clarke, D. C., Betterton, M. D., Liu, X.
openaire +3 more sources
Single-cell-based system to monitor carrier driven cellular auxin homeostasis [PDF]
, 2013 Background: Abundance and distribution of the plant hormone auxin play important roles in plant development. Besides other metabolic processes, various auxin carriers control the cellular level of active auxin and, hence, are major regulators of cellular
Barbez, Elke +7 more
core +3 more sources
Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. [PDF]
, 2019 During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Chhabra, Sapna +4 more
core +1 more source
Evolution of the Calcium-Based Intracellular Signaling System
Genome Biology and Evolution, 2016 To progress our understanding of molecular evolution from a collection of well-studied genes toward the level of the cell, we must consider whole systems. Here, we reveal the evolution of an important intracellular signaling system. The calcium-signaling
E. Marchadier +5 more
semanticscholar +1 more source
Content in Simple Signalling Systems [PDF]
The British Journal for the Philosophy of Science, 2018 Our understanding of communication and its evolution has advanced significantly through the study of simple models involving interacting senders and receivers of signals. Many theorists have thought that the resources of mathematical information theory are all that are needed to capture the meaning or content that is being communicated in these systems.
Shea, N, Godfrey-Smith, P, Cao, R
openaire +5 more sources