Results 21 to 30 of about 1,690,858 (268)

Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA

Nature Communications
The immunologic consequences of using bactericidal versus bacteriostatic antibiotic treatments are unclear. We observed a bacteriostatic (growth halting) treatment was more protective than a bactericidal (bacteria killing) treatment in a murine ...
Julia L. Gross, Rahul Basu, Clinton J. Bradfield, Jing Sun, Sinu P. John, Sanchita Das, John P. Dekker, David S. Weiss, Iain D. C. Fraser   +8 more
doaj   +1 more source

One-Leg Half-Bridge Diode-Clamped Four-Level PWM Inverter Based on MNRV PWM

IEEE Access
This paper introduces a one-leg half-bridge (HB) diode-clamped four-level PWM inverter incorporating the multi-neighboring reference vector pulse-width modulation (MNRV PWM) methodology.
Min-Sup Song, Hyungchul Kim
doaj   +1 more source

A HOSPITAL SIGNAL SYSTEM. [PDF]

JAMA: The Journal of the American Medical Association, 1907
In October, 1904, I devised, for the Hospital of the Good Samaritan, a signal system for calling nurses to patients, which has the following advantages: Noiseless. There being no bells, the call is absolutely silent. Monitor board. This is in the office of the superintendent of nurses and enables this officer or her representatives to observe each ...
openaire   +2 more sources

The Ubiquitin System and Jasmonate Signaling [PDF]

Plants, 2016
The ubiquitin (Ub) system is involved in most, if not all, biological processes in eukaryotes. The major specificity determinants of this system are the E3 ligases, which bind and ubiquitinate specific sets of proteins and are thereby responsible for target recruitment to the proteasome or other cellular processing machineries.
Astrid Nagels Durand, Laurens Pauwels, Alain Goossens   +2 more
openaire   +3 more sources

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Systems theory of Smad signalling [PDF]

IEE Proceedings - Systems Biology, 2006
Transforming Growth Factor-beta (TGF-beta) signalling is an important regulator of cellular growth and differentiation. The principal intracellular mediators of TGF-beta signalling are the Smad proteins, which upon TGF-beta stimulation accumulate in the nucleus and regulate transcription of target genes.
Clarke, D. C., Betterton, M. D., Liu, X.
openaire   +3 more sources

Acute Neurological Events in Children With Hemoglobin SC Disease: A Multicenter Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.
Célia Paulmin, Bérengère Koehl, Audrey Maudoux, Hanine Mansour, Marie‐Hélène Odievre, Nathalie Garrec, Emilie Georget, Cécile Arnaud, Slimane Allali, Lydia Doumdo, Marie Belloy, Corinne Guitton   +11 more
wiley   +1 more source

A Preliminary Study on 2D Convolutional Neural Network-Based Discontinuous Rail Position Classification for Detection on Rail Breaks Using Distributed Acoustic Sensing Data

IET Electrical Systems in Transportation
Rail breaks, which are crucial maintenance issues for the railways, require immediate inspection and maintenance as it can cause severe railway accidents. Though, it is still difficult to promptly detect rail breaks that occur during train operation even
Hye-Yeun Chun, Jungtai Kim, Dongkue Kim, Ilmu Byun, Kyeongjun Ko   +4 more
doaj   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Content in Simple Signalling Systems [PDF]

The British Journal for the Philosophy of Science, 2018
Our understanding of communication and its evolution has advanced significantly through the study of simple models involving interacting senders and receivers of signals. Many theorists have thought that the resources of mathematical information theory are all that are needed to capture the meaning or content that is being communicated in these systems.
Shea, N, Godfrey-Smith, P, Cao, R
openaire   +5 more sources