Results 11 to 20 of about 19,728,514 (315)

An Overview of Potential Therapeutic Agents Targeting WNT/PCP Signaling

, 2021
Since the discovery of the proto-oncogene Wnt1 (Int1) in 1982, WNT signaling has been identified as one of the most important pathways that regulates a wide range of fundamental developmental and physiological processes in multicellular organisms.
Jin Wang, Wang, J, Feng, D, Bo Gao, Di Feng, Gao, B   +5 more
core   +1 more source

Hedgehog Signaling in Cortical Development [PDF]

, 2023
The Hedgehog (Hh) pathway plays a crucial role in embryonic development, acting both as a morphogenic signal that organizes tissue formation and a potent mitogenic signal driving cell proliferation.
Xuecai Ge, Cai, Eva, Ge, Xuecai, Maximiliano Gonzalez Barba, Barba, Maximiliano Gonzalez, Eva Cai   +5 more
core   +1 more source

Full-Bridge Diode-Clamped Four-Level Symmetric Switching Converter

IEEE Access, 2023
In this paper, we propose a novel full-bridge (FB) diode-clamped four-level symmetric switching converter. Multi-neighboring reference vector discontinuous PWM (MNRV DPWM) for FB topology was implemented using a symmetric half-bridge (HB)-based control ...
Min-Sup Song, Jaewon Kim, Jae-Bum Lee
doaj   +1 more source

Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake

Molecular Metabolism, 2014
Objective: Leptin responsive neurons play an important role in energy homeostasis, controlling specific autonomic, behavioral, and neuroendocrine functions.
Kavon Rezai-Zadeh, Sanghou Yu, Yanyan Jiang, Amanda Laque, Candice Schwartzenburg, Christopher D. Morrison, Andrei V. Derbenev, Andrea Zsombok, Heike Münzberg   +8 more
doaj   +1 more source

Phosphate sink containing two-component signaling systems as tunable threshold devices [PDF]

, 2014
Synthetic biology aims to design de novo biological systems and reengineer existing ones. These efforts have mostly focused on transcriptional circuits, with reengineering of signaling circuits hampered by limited understanding of their systems dynamics ...
Elisenda Feliu (481165), Soyer, Orkun S, Birgit E. Scharf (652091), Steven L Porter, Orkun S. Soyer (242985), Varun B. Kothamachu (481164), Munia Amin, Kothamachu, Varun B., Soyer, Orkun S., Birgit E Scharf, Elisenda Feliu, Scharf, Birgit E, Varun B Kothamachu, Munia Amin (386302), Amin, Munia, Kothamachu, Varun B, Steven L. Porter (243401), Porter, Steven L., Orkun S Soyer, Porter, Steven L, Feliu, Elisenda, Scharf, Birgit E.   +21 more
core   +2 more sources

Performance Evaluation of Signaling in the IP QoS System

Journal of Telecommunications and Information Technology, 2023
The IP QoS System is based on next generation networks (NGN) and differentiated services (DiffServ) architectures. Its main part is a signaling system, which allows to send a request from a user to the system for establishing new connection with ...
Halina Tarasiuk, Jarosław Śliwiński, Przemysław Jaskóła, Witold Góralski   +3 more
doaj   +1 more source

Notch2 signaling in development and cancer [PDF]

, 2012
Notch signaling via cell to cell interaction is a key mechanism in regulating proliferation, cell fate decisions and survival of various cell types in both invertebrates and vertebrates.
Tchorz, Jan Stephan
core   +1 more source

Alternate transcription of the Toll-like receptor signaling cascade [PDF]

, 2006
Alternate splicing of key signaling molecules in the Toll-like receptor (Tlr) cascade has been shown to dramatically alter the signaling capacity of inflammatory cells, but it is not known how common this mechanism is. We provide transcriptional evidence
Kai, Chikatoshi, Forrest, A, Schroder, K, Forrest, Alistair, Kawai, J, Kawaji, H, Wells, Christine A, Faulkner, G, Carninci, P, Hume, DA, Carninci, Piero, Grimmond, SM, Himes, SR, Lo, Sandra, Hume, David, Schroder, Kate, Taylor, D, Grimmond, Sean M, Faulkner, Geoffrey, Chalk, Alistair, Kasukawa, T, Himes, S Roy, Grimmond, Sean, Kawai, Jun, Waddell, Nic, Lo, Yu-Lan Sandra, Hayashizaki, Yoshihide, Kasukawa, Takeya, Wells, Christine, Katayama, S, Hayashizaki, Y, Chalk, Alistair M, Katayama, Shintaro, Hume, David A, Chalk, AM, Taylor, Darrin, Kawaji, Hideya, Wells, CA, Waddell, N, Lo, S, Kai, C   +40 more
core   +1 more source

Signals and systems.

Genome biology, 2006
A report on the 2006 Keystone Conference on Signaling Networks, Vancouver, Canada, 30 January-4 February 2006.
Krogan, Nevan J, Hughes, Timothy R
openaire   +2 more sources

Integrated signaling pathway and gene expression regulatory model to dissect dynamics of Escherichia coli challenged mammary epithelial cells [PDF]

, 2014
Cells transform external stimuli, through the activation of signaling pathways, which in turn activate gene regulatory networks, in gene expression. As more omics data are generated from experiments, eliciting the integrated relationship between the ...
den Breems, NY, den Breems, Nicoline Y., Kulasiri, Don, Nguyen, LK, Nguyen, Lan K.   +4 more
core   +1 more source