Results 1 to 10 of about 24,330 (235)

TAD boundaries and gene activity are uncoupled [PDF]

eLife
Topologically associating domains (TADs) are prominent features of genome organization. A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs.
Faisal Almansour, Nadezda A Fursova, Adib Keikhosravi, Kathleen S Metz Reed, Daniel R Larson, Gianluca Pegoraro, Tom Misteli   +6 more
doaj   +2 more sources

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization [PDF]

Advanced Science
Background: Thoracic aortic dissection (TAD) is a lethal vascular emergency lacking targeted therapies. Fibroblast activation protein (FAP), a protease implicated in tissue remodeling, exhibits unknown roles in TAD pathogenesis.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
doaj   +2 more sources

A 4-Decade Population-Based Registry of Thoracic Aortic Dissection Causing Sudden Death in the Young [PDF]

JACC: Advances
Background: Thoracic aortic dissection (TAD) causing sudden cardiac death (SCD) in the young is overlooked and poorly described. Objectives: The purpose of this study was to assess: 1) the incidence of TAD-related SCD, and 2) the prevalence and features ...
Monica De Gaspari, MD, PhD, Cristina Basso, MD, PhD, Francesca Dalla Zanna, BSc, Maria Bueno Marinas, PhD, Marco Cason, PhD, Rudy Celeghin, PhD, Serena Pinci, BSc, Martina Perazzolo Marra, MD, PhD, Domenico Corrado, MD, PhD, Ugo Fedeli, MD, Hector I. Michelena, MD, Stefano Nistri, MD, PhD, Gaetano Thiene, MD, Kalliopi Pilichou, PhD, Stefania Rizzo, MD, PhD   +14 more
doaj   +2 more sources

Tad pili contribute to the virulence and biofilm formation of virulent Aeromonas hydrophila

Frontiers in Cellular and Infection Microbiology
Type IV pili (T4P) are versatile proteinaceous protrusions that mediate diverse bacterial processes, including adhesion, motility, and biofilm formation. Aeromonas hydrophila, a Gram-negative facultative anaerobe, causes disease in a wide range of hosts.
Jochen Blom, Hasan C Tekedar, Larry Hanson   +2 more
exaly   +3 more sources

The Impact of COVID-19 on Hospitalised COPD Exacerbations in Malta

Pulmonary Medicine, 2021
Introduction and Aims. The first COVID-19 case in Malta was confirmed on the 7th of March 2020. This study is aimed at investigating a significant difference between the number of acute exacerbations of chronic obstructive pulmonary disease (AECOPD ...
Yvette Farrugia, Bernard Paul Spiteri Meilak, Neil Grech, Rachelle Asciak, Liberato Camilleri, Stephen Montefort, Christopher Zammit   +6 more
doaj   +1 more source

A reflection on Animación.es, a history of animation in Spain in an exhibition

Con A de Animación, 2021
On 13th June 2021, Animación.es: una historia en una exposición closed its doors at the Imprenta Municipal de Madrid. It was the largest exhibition held to date on the history and production processes of Spanish animation and it had to face an extremely ...
José Antonio Rodríguez Díaz, Samuel Viñolo Locubiche   +1 more
doaj   +1 more source

A TAD closer to ATM [PDF]

Molecular & Cellular Oncology, 2016
Ataxia telangiectasia mutated (ATM) has been known for decades as the main kinase mediating the DNA double-strand break response. Our recent findings suggest that its major role at the sites of breaks likely resides in its ability to modify both the local chromatin landscape and the global chromosome organization in order to promote repair accuracy.
Aymard, Francois, Legube, Gaëlle
openaire   +2 more sources

Multiple cardiac metastases from urothelial carcinoma case report

The Egyptian Heart Journal, 2022
Background Cardiac metastases are rare and frequently remain undiagnosed due to the absence of clinical signs in the majority of cases. Malignancies found to most commonly metastasise to the heart include lung carcinoma, breast carcinoma and lymphoma ...
Neil Grech, William Camilleri, Alexander Borg   +2 more
doaj   +1 more source

TADs or no TADS: Lessons From Single-cell Imaging of Chromosome Architecture [PDF]

Journal of Molecular Biology, 2020
Eukaryotic genomes are folded in a hierarchical organization that reflects and possibly regulates their function. Genomewide studies revealed a new level of organization at the kilobase-to-megabase scale termed "topological associating domains" (TADs).
Gizzi, Andrés M Cardozo, Cattoni, Diego I, Nollmann, Marcelo   +2 more
openaire   +3 more sources

Beyond the coding genome: non-coding mutations and cancer

Frontiers in Bioscience-Landmark, 2020
Latest advancements in genomics involving individuals from different races and geographical locations has led to the identification of thousands of common as well as rare genetic variants and copy number variations (CNVs). These studies have surprisingly
Kaivalya Walavalkar, Dimple Notani
doaj   +1 more source