Results 11 to 20 of about 50,398 (264)
TADs or no TADS: Lessons From Single-cell Imaging of Chromosome Architecture [PDF]
Journal of Molecular Biology, 2020 Eukaryotic genomes are folded in a hierarchical organization that reflects and possibly regulates their function. Genomewide studies revealed a new level of organization at the kilobase-to-megabase scale termed "topological associating domains" (TADs).
Gizzi, Andrés M Cardozo +2 more
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Molecular & Cellular Oncology, 2016 Ataxia telangiectasia mutated (ATM) has been known for decades as the main kinase mediating the DNA double-strand break response. Our recent findings suggest that its major role at the sites of breaks likely resides in its ability to modify both the local chromatin landscape and the global chromosome organization in order to promote repair accuracy.
Aymard, Francois, Legube, Gaëlle
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STRIDE: A Sequencing Depth Robust Metric for Sparse Chromosome Conformation Capture Data Comparison. [PDF]
Adv Sci (Weinh)A mean first passage time (MFPT)‐based representation transforms sparse Hi‐C contact maps into robust topological representations, preserving biologically meaningful chromatin features and facilitating robust analysis of TADs, chromatin loops, differential chromatin contacts, and sparse single‐cell Hi‐C data.
Xu B, Gao X, Tao W, Zhang Z, Li F.
europepmc +2 more sources
Multi-Layer Transcriptomic Comparison Across Human, Pig, and Mouse Informs Tissue- and Trait-Specific Animal Model Selection. [PDF]
Adv Sci (Weinh)We integrated RNA‐seq data from humans, pigs, and mice across 15 matched tissues based on 14 910 one‐to‐one orthologous genes. Cross‐species similarity was systematically evaluated across multiple regulatory layers, including global co‐expression conservation, co‐expression networks, tissue‐specific programs, and 3D genome architecture.
Dou J +21 more
europepmc +2 more sources
Scholars Journal of Dental Sciences, 2021 Anchorage is one of the important aspects of orthodontic treatment TAD have gained profound applications in contemporary orthodontic protocol. To treat almost every genre of malocclusion be it arising from dentoalveolar component, skeletal component or combination of both Various skeletal anchorage devices were introduced in the 20th century which ...
Sharath Kumar Shetty +3 more
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Comparison of chicken iPSCs with PB-R6F and PB-TAD-7F.
, 2023 a: Structure of reprogramming vector. b: Images of chicken iPSCs transfected with PB-R6F and PB-TAD-7F. Left: chicken iPSCs with PB-R6F; right: chicken iPSCs with PB-TAD-7F. The bars represent 500 μm (PB-R6F) and 200 μm (PB-TAD-7F).
Masafumi Katayama (7309766) +4 more
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Efficient Reaction Space Exploration with ChemTraYzer-TAD
, 2022 The development of a reaction model is often a time-consuming process, especially if unknown reactions have to be found and quantified. To alleviate the reaction modeling process, automated procedures for reaction space exploration are highly desired. We
Wassja Kopp +11 more
core +1 more source
Nature Reviews Genetics, 2019 A study in Nature Genetics shows that genomic rearrangements that cause extensive changes to chromatin topology do not alter expression for the majority of genes.
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dftd3/tad-dftd3: Torch autodiff DFT-D3 version 0.0.2
, 2022 Changelog <ul> <li>fix dimensions of reference C6 coefficients</li> <li>add helper routine for masking</li> <li>ensure autodiff w.r.t.
Sebastian Ehlert
core +1 more source
Nucleic Acids Research, 2018 Topologically associating domains (TADs) are megabase-sized building blocks of interphase chromosomes in higher eukaryotes. TADs are chromosomal regions with increased frequency of internal interactions. On average a pair of loci separated by a given genomic distance contact each other 2-3 times more frequently when they are in the same TAD as compared
Dusan Racko +3 more
openaire +5 more sources