Results 61 to 70 of about 24,330 (235)

Videojuegos como espacios de interacción: preferencias y prácticas de los nativos digitales en España

Área Abierta
Los videojuegos constituyen una dinámica de entretenimiento y de interacción muy popular entre los jóvenes. Este trabajo analiza las actitudes y valoraciones de las generaciones Millennials y Z en España hacia la interacción a través de los videojuegos ...
Cristina Ruiz-Poveda Vera, José María Jiménez Peláez, Juana Rubio Romero   +2 more
doaj   +1 more source

Exploring the Socio‐Economic Toll of Non‐Communicable Diseases in Low‐Resource Settings: Novel Evidence From Mozambique

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Background The socio‐economic burden of increasingly prevalent non‐communicable diseases (NCDs) in low‐income countries is substantial and widely recognised. This study aimed to fill the remaining evidence gap for type 2 diabetes (T2DM) and hypertension (HTN) patients in selected health facilities across two provinces in Mozambique.
Maria Verykiou, Paolo Belardi, Sandra Loureiro, Paolo Massaro, Fernando Chenene, Celina Mate, Celeste Amado, Armindo Daniel Tiago, Giovanni Putoto, Aleksandra Torbica   +9 more
wiley   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, EarlyView.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

NKX2‐1 Downstream Regulatory Structural Variants Explain a Substantial Proportion of Molecular Diagnoses in Patients With Benign Hereditary Chorea

Movement Disorders, EarlyView.
Abstract Background NKX2‐1–related disorders (NKX2‐1‐RDs) classically present with a triad of neurological, endocrine, and pulmonary manifestations, including benign hereditary chorea. However, in a fraction of patients, NKX2‐1 coding variants are not detected, and variants outside the NKX2‐1 locus have been reported.
Robin Wijngaard, Lucy Dougherty‐de Miguel, German Demidov, Galuh Astuti, Amaia Lasa‐Aranzasti, Ana Cueto‐González, Marta Correa‐Vela, Carlos Lázaro‐Hernández, Charlotte A. Haaxma, Clara D.M. van Karnebeek, David Gómez‐Andrés, Ignacio Iglesias‐Serrano, Jiddeke M. van de Kamp, Jolanda Schieving, Laura Trujillano, Marc Engelen, Beatriz Muñoz‐Cabello, Roderick P.P.W.M. Maas, Thatjana Gardeitchik, Victoria Gonzalez, Annemarie de Vreugd, Cristina Pérez‐Sanchez, Elisabet Lloveras, Erik‐Jan Kamsteeg, Maartje Pennings, Natalia Rey‐Viñets, Javier Sánchez, Ronald van Beek, Antonio Moreno‐Galdó, Lisenka E.L.M. Vissers, Kornelia Neveling, Anna Marcé‐Grau, Machteld M. Oud, Belén Pérez‐Dueñas   +33 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Structural Variation Sequencing of 26 Amniotic Fluid Samples With Partial Gene Duplications and Postnatal Follow‐Up of the Fetuses

Prenatal Diagnosis, EarlyView.
ABSTRACT Objectives Partial gene duplications (PGDups) are a significant contributor to genetic disease. The precise genomic location and structure of PGDups are often unresolved using conventional methods, so prenatal diagnosis for PGDups is challenging, especially without ultrasound abnormalities.
Shengfang Qin, Xueyan Wang, Mengjia Yan, Yuxia He, Zhuo Zhang, Yan Yin, Jin Wang, Beibei Guo, Jing Wang, Na Xi, Zhaokai Li   +10 more
wiley   +1 more source

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner   +2 more
wiley   +1 more source

Dual Quantum Dot Molecular FRET Probes for Picomolar DNA Hexaplexing

Small Methods, EarlyView.
Multiplexed quantification of six different DNA targets from a single 200 µL sample at picomolar concentrations was accomplished by spectrotemporal detection of time‐resolved FRET from a single Tb‐complex donor to two quantum dot acceptors using one‐color excitation and two‐color detection.
Ruifang Su, Federico Pini, Nour Fayad, Kimihiro Susumu, Marta M. Natile, Igor L. Medintz, Thibault Gallavardin, Thomas J. Sørensen, Niko Hildebrandt   +8 more
wiley   +1 more source

Two‐Stage Power Management for Triboelectric Nanogenerators: Toward Reliable and Efficient Self‐Powered Systems

Safety Science and Technology, EarlyView.
This review systematically outlines two‐stage power management circuits for TENGs, integrating AC–DC and DC–DC conversion to overcome high impedance and unstable output. It highlights strategies for efficient energy extraction and stable power delivery, enabling the development of reliable self‐powered systems for safety monitoring and applications in ...
Jiaxin Hu, Zhiyong Zhang, Haiyang Shao, Tianyu Shi, Baoling Yuan, Ming‐Lai Fu   +5 more
wiley   +1 more source

El Diluvio Digital. Las preguntas esenciales de las humanidades en la sociedad Red.

Arte y Sociedad, 2019
Nuestra relación con el medio social está condicionada por flujos de información en los que las tecnologías digitales transforman cualquier aproximación y comprensión de los fenómenos culturales.
Jaime Repollés Llauradó
doaj