Results 81 to 90 of about 2,066 (198)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

A comprehensive benchmarking with interpretation and operational guidance for the hierarchy of topologically associating domains

Nature Communications
Topologically associating domains (TADs), megabase-scale features of chromatin spatial architecture, are organized in a domain-within-domain TAD hierarchy.
Jingxuan Xu, Xiang Xu, Dandan Huang, Yawen Luo, Lin Lin, Xuemei Bai, Yang Zheng, Qian Yang, Yu Cheng, An Huang, Jingyi Shi, Xiaochen Bo, Jin Gu, Hebing Chen   +13 more
doaj   +1 more source

Challenging the prokaryotic MGE‐defense origin of eukaryotic RNA editing

mLife, EarlyView.
Yuange Duan, Qiuhua Xie, Jiajia Yang, Wanzhi Cai, Hu Li   +4 more
wiley   +1 more source

Exploring Appropriate Positioning of the Spiral Blade in Treatment of Subtrochanteric Fractures of the Femur Using Proximal Femoral Nail Antirotation

Orthopaedic Surgery
Objectives Subtrochanteric fractures have anatomic characteristics distinct from intertrochanteric fractures that may affect the positioning of the spiral blade during surgical treatment.
Qingyan Zhang, Xiaogang Wang, Longhui Su, Qiang Xu   +3 more
doaj   +1 more source

Influence of mobility and work–family conflict on U.S. military spouse employment

Family Relations, EarlyView.
ABSTRACT Objective This study longitudinally assessed how mobility across geographic regions and work–family conflict influenced spouse employment trajectories and perceptions of career hindrance. Background The unemployment rate for U.S. military spouses has remained 21% since 2015 with specific aspects of military life, such as moving, reported as ...
Kelly A. Woodall, Claire A. Kolaja, Hope M. McMaster, Rudolph P. Rull, Andrew Furne, Nicholas J. Armstrong, Valerie A. Stander, the Millennium Cohort Family Study Team, Rani Duff, Anna Garner, Danielle Hunt, Dana Maglic, Sharmini Radakrishnan, Isabel Altarejos, Lauren Bauer, Sarah Carinio, Alex Esquivel, Travis Ray, Sabrina Richardson, Karen Tannenbaum   +19 more
wiley   +1 more source

Modeling Thoracic Aortic Dissection Using Patient-Specific iPSCs Reveals VSMC Dysfunction and Extracellular Matrix Dysregulation

Stem Cells International
Thoracic aortic dissection (TAD) is a life-threatening condition characterized by medial degeneration and vascular smooth muscle cell (VSMC) dysfunction, with no effective medical therapy currently available. The underlying pathological mechanisms of TAD
Peifeng Jin, Yubin Xu, Sixian Wang, Lu Ding, Yuhao Chen, Miqi Zhou, Xiufang Chen, Xiaofang Fan, Yongsheng Gong, Ming Li, Yongyu Wang   +10 more
doaj   +1 more source

The Reduction of COMP Serves as a Predictor for Warning of Aortic Dissection Progression

JACC: Basic to Translational Science
Thoracic aortic dissection (TAD) is a life-threatening cardiovascular disease that is associated with high morbidity and mortality. The prevailing challenge in TAD monitoring and diagnosis is the lack of novel biomarkers.
Zhuofan Li, BS, Ze Gong, PhD, Weihao Li, MD, Yanghui Chen, PhD, Rongbo Dai, PhD, Shiyu Yang, BS, Yufei Chen, PhD, Fang Yu, MS, Yi Fu, MBBS, PhD, Wei Li, MD, Dao Wen Wang, MD, PhD, Yiting Jia, PhD, Wei Kong, MD, PhD   +12 more
doaj   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

A 4-Decade Population-Based Registry of Thoracic Aortic Dissection Causing Sudden Death in the Young

JACC: Advances
Background: Thoracic aortic dissection (TAD) causing sudden cardiac death (SCD) in the young is overlooked and poorly described. Objectives: The purpose of this study was to assess: 1) the incidence of TAD-related SCD, and 2) the prevalence and features ...
Monica De Gaspari, MD, PhD, Cristina Basso, MD, PhD, Francesca Dalla Zanna, BSc, Maria Bueno Marinas, PhD, Marco Cason, PhD, Rudy Celeghin, PhD, Serena Pinci, BSc, Martina Perazzolo Marra, MD, PhD, Domenico Corrado, MD, PhD, Ugo Fedeli, MD, Hector I. Michelena, MD, Stefano Nistri, MD, PhD, Gaetano Thiene, MD, Kalliopi Pilichou, PhD, Stefania Rizzo, MD, PhD   +14 more
doaj   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source