Results 171 to 180 of about 95,530 (267)

Methods to estimate marine functional connectivity: A primer. [PDF]

Ecol Appl
Sturrock AM, Tanner SE, Arnaud-Haond S, Aguzzi J, Barboza FR, Beger M, Blanco A, Brophy D, Carreton M, Childs AR, Costantini F, Gaggiotti OE, Gillanders BM, González-Irusta JM, Guizien K, Guy-Haim T, Haase S, Hunter E, Kotta J, Lacroix G, Öztürk RÇ, Pérez-Ruzafa A, Reis-Santos P, Riginos C, Rilov G, Rinkevich B, Rotllant G, Secor DH, Smoliński S, Trueman CN, Walther BD, Darnaude AM.   +31 more
europepmc   +1 more source

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

Advanced Materials, EarlyView.
Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot, Sebastian Jung, Sébastien Harlepp, Alexandre Detappe   +3 more
wiley   +1 more source

Covalent Chemical Tagging of Transmembrane Transport Proteins Illuminates the Internalization Pathways of Xenosiderophores. [PDF]

J Am Chem Soc
Cao M, Huynh M, Josts I, Lao Y, Dang HH, Marlin A, Huang X, Tidow H, Boros E.   +8 more
europepmc   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Impairment of novelty-dependent hippocampal behavioural tagging in Septin5-deficient mice. [PDF]

Mol Brain
Ageta-Ishihara N, Fukumasu N, Fujii K, Koshidaka Y, Tanigaki K, Hiramoto T, Kang G, Hiroi N, Miyakawa T, Takao K, Kinoshita M.   +10 more
europepmc   +1 more source

Transient Cytoskeletal Anisotropy Encodes Short‐Term Mechanical Memory in Glioblastoma Cells

Advanced Materials, EarlyView.
The same mechanical deformation can produce distinct cytoskeletal states depending on loading history. Experiments and constitutive modeling reveal that transient actin–vimentin anisotropy stores mechanical information and governs short‐term mechanical memory in glioblastoma cells.
Clara Gomez‐Cruz, Matthieu Gelin, Lucas Pradeau‐Phélut, Arrate Muñoz‐Barrutia, Sandrine Etienne‐Manneville, Daniel Garcia‐Gonzalez   +5 more
wiley   +1 more source

Development and Evaluation of Exosporium-Anchored Bioluminescent and Fluorescent Reporters for Tracking <i>Clostridioides difficile</i> Spores Formed <i>In Vivo</i>. [PDF]

ACS Synth Biol
Lopez-Garcia OK, Hejtmancik T, Pizarro-Guajardo M, Brehm L, Brito-Silva C, Paredes-Sabja D.   +5 more
europepmc   +1 more source

Spatial Control of Light‐Responsive Proteins and Optogenetics Within Hydrogels via Volumetric Bioprinting

Advanced Materials, EarlyView.
Spatiotemporal control over cell behavior within bioprinted constructs remains a key challenge in biofabrication. Volumetric bioprinting using multi‐wavelength light sources permits to activate light‐sensitive intracellular proteins as well as optogenetic gene and protein expression circuits in bioprinted cells, in addition to enabling fast printing of
Davide Ribezzi, Pere Català, Gabriel Größbacher, Paulina Nuñez Bernal, Olaf Nijssen, Sammy Florczak, Wilco Nijenhuis, Nuria Crusellas‐Villorbina, Bram Nijhoff, Paul Delrot, Jos Malda, Andreas Hierholzer, Martin Fussenegger, Lukas C. Kapitein, Riccardo Levato   +14 more
wiley   +1 more source

Dolphinfish (Coryphaena hippurus) Biologging Dataset in the Eastern Pacific Ocean. [PDF]

Sci Data
Perle CR, O'Sullivan J, Ortega-Garcia S, Rodriguez-Sanchez R, McKinzie M, Koch SS.   +5 more
europepmc   +1 more source

Ultrafast Postcolumn Microdroplet Derivatization of Nucleobases for Enhanced Online Detection, Characterization, and Quantification of Nucleic Acid Modifications Using LC-MS². [PDF]

Anal Chem
Do QT, Kafeenah H, Huang CH, Chen SH.
europepmc   +1 more source