Results 201 to 210 of about 95,530 (267)

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

<i>trans</i>-Translation inhibitors that kill <i>Mycobacterium tuberculosis</i> and pathogenic non-tuberculous mycobacteria also disrupt metal homeostasis. [PDF]

Microbiology (Reading)
Varshney A, Jia Z, Gebretsadik G, G-Dayanandan N, Bowlin TL, Butler MM, Baughn AD, Keiler KC.   +7 more
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

High annual-cycle repeatability suggests low flexibility to environmental changes in a near-threatened migratory shorebird. [PDF]

Commun Biol
Schwemmer P, Donnez M, Mercker M, Garthe S, Boschert M, Düttmann H, Elts J, Fartmann T, Fiedler W, Jiguet F, Kämpfer S, Korniluk M, Kruckenberg H, Krupiński D, Marja R, Piha M, Rousseau P, Rupprecht V, Bocher P.   +18 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

UzbekPOS: A multi-domain dataset for Uzbek part-of-speech tagging. [PDF]

Data Brief
Sharipov M, Kuriyozov E, Vičič J.
europepmc   +1 more source

CliniCAM: A Technical Report of a Mobile Health Application for Structured Clinical Image Documentation and Tag-Based Dataset Generation. [PDF]

Cureus
De Alba Solis AU, Gómez Sánchez E.
europepmc   +1 more source

dFlpTag, a RMCE-based tool for simultaneous endogenous protein tagging and cell labeling in Drosophila. [PDF]

Sci Rep
Li L, Yan J, Ruan Y, Dyson MC, Laenen F, Liu S, Xie X.   +6 more
europepmc   +1 more source

Harnessing intrinsic cardiac motion vs. external mechanical vibrations: a comparison of MRI cine-tagging and MR elastography for liver fibrosis assessment. [PDF]

Br J Radiol
Lefebvre TL, Volniansky A, Petitclerc L, Montagnon E, Sebastiani G, Giard JM, Sylvestre MP, Nguyen BN, Gilbert G, Cloutier G, Tang A.   +10 more
europepmc   +1 more source

Aromaticity-driven laser photo-responses and binding efficiency in IAF-conjugated natural products for neurodegenerative disease targets. [PDF]

Signal Transduct Target Ther
Nik Zulkarnine NH, Faramarzi V, Hwang MT.   +2 more
europepmc   +1 more source