Results 281 to 290 of about 458,059 (348)

An individual-based model of North Pacific albacore tuna seasonal migratory behaviour and climate sensitivity. [PDF]

Sci Rep
Davidson LA, Erdozain CM, Drake CR, Di Lorenzo E, Muhling BA, Koch SS.   +5 more
europepmc   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Sensorimotor Frequency Tagging Is Enhanced by Auditory and Audiovisual but Not Visual, Inputs During a Body-Walking Task. [PDF]

Psychophysiology
Matamala-Gomez M, Vilà-Balló A, Cucurell D, Tajadura-Jiménez A, Rodriguez-Fornells A.   +4 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Refining Electronic Tagging of Marine Animals: Computational Fluid Dynamics and Pelagic Sharks. [PDF]

Animals (Basel)
Maillard TC, Garzon F, Hawkes LA, Tabor GR, Witt MJ.   +4 more
europepmc   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

MyoNet: Deep Learning-Based Myocardial Strain Quantification from Cine Cardiac MRI. [PDF]

Bioengineering (Basel)
An D, Nencka A, Clarysse P, Croisille P, Bergom C, Ibrahim ES.   +5 more
europepmc   +1 more source

Automated Multitier Tagging of Chinese Online Health Education Resources Using a Large Language Model: Development and Validation Study.

J Med Internet Res
Meng J, Dai R, Huang X, Gu Y, Yan S, Wang X, Gao J, Zhang TT.   +7 more
europepmc   +1 more source

Design of bifunctional RNA-binding compounds that can modulate siRNA hydrophobicity for deep penetration and gene silencing in the retina. [PDF]

Mol Ther Nucleic Acids
Mao Q, Quan Y, Chen S, Tai W.
europepmc   +1 more source

MedicalPhoto: Open-Source Clinical Photo Management Software for Digital Transformation. [PDF]

Ann Dermatol
Kim MS, Chang SE, Kim GH, Navarrete-Dechent C, Kim S, Kim SH, Han SS.   +6 more
europepmc   +1 more source