Results 211 to 220 of about 1,132,441 (330)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Quark-Gluon Tagging: Machine Learning meets Reality

, 2018
Gregor Kasieczka, Nicholas M. Kiefer, Tilman Plehn, J. Thompson   +3 more
openalex   +1 more source

Metagenomic 16S rDNA Illumina tags are a powerful alternative to amplicon sequencing to explore diversity and structure of microbial communities.

Environmental Microbiology, 2014
R. Logares, S. Sunagawa, Guillem Salazar, Francisco M. Cornejo-Castillo, I. Ferrera, H. Sarmento, P. Hingamp, H. Ogata, C. de Vargas, G. Lima-Mendez, J. Raes, J. Poulain, O. Jaillon, P. Wincker, S. Kandels-Lewis, E. Karsenti, P. Bork, S. Acinas   +17 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Non-Fistulizing Perianal Disease in Crohn's Disease: Clinical Significance, Pathogenesis, and Management Strategies. [PDF]

J Clin Med
Abreu Marques I, Cúrdia Gonçalves T, Macedo C, Campelo P, Cotter J.   +4 more
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Insights into the Performance of CusF as a Solubility Tag for Recombinant Protein Expression. [PDF]

Int J Mol Sci
Oscorbin IP, Smertina MA, Kunova MS, Filipenko ML.   +3 more
europepmc   +1 more source

Using Tags and Latent Factors in a Food Recommender System

Digital Health, 2015
Mouzhi Ge, Mehdi Elahi, Ignacio Fernández-Tobías, F. Ricci, David Massimo   +4 more
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Examination of the Communication Environment When Applying Removable Dentures as Wearable Devices. [PDF]

Cureus
Iwata Y, Yanagizono Y, Iida T, Ashida Y, Yamada Y, Asano T, Suzuki H, Tsuge T, Komiyama O, Niitsu K.   +9 more
europepmc   +1 more source