Results 71 to 80 of about 1,206,916 (256)

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Effect of Tai Chi Practice on Stress, Self-Esteem, and Perceived Life Expectancy and a Structural Model of Relation Among These Variables Taking Into Account Age

SAGE Open, 2014
The aims of this article were to (a) investigate whether practicing Tai Chi has an effect on stress, self-esteem, and perceived life expectancy and (b) contrast a structural model of relation between the three latter variables taking into account age ...
José Moral de la Rubia, Adrian Valle de la O, Cirilo H. García Cadena, Luis A. Pérez Góngora   +3 more
doaj   +1 more source

The holistic approach in Parkinson disease s prevention and rehabilitation: effectivness of Tai Chi Chuan and Qi Gong s practise for a better quality of life

, 2022
reservedIl presente lavoro é stato concepito per esaminare la letteratura legata alle terapie complementari quali Tai Chi Chuan e Qi Gong per la prevenzione e la riabilitazione del del Morbo di ParkinsonThis elaboration has ben conceived to examinate
PARUSCIO, KATIA
core  

Front‐Loading Zn2+ via Lattice‐Breathing‐Enabled Early‐Stage Co‐Intercalation for Ultrastable Zn‐Ion Batteries

Advanced Science, EarlyView.
This study introduces In3+ into δ‐MnO2 to create a lattice breathing effect via a dynamic strain field, which establishes efficient ″ polaronic superhighways″ for charge transport. We uncover an unconventional two‐stage (Zn2+/H+ co‐insertion followed by Zn2+‐dominant) mechanism that enables reversible structural adjustment. This approach simultaneously
Haitao Li, Min Bu, Songlin Li, Huili Cao, Qi Lei, Yang Wang, Limin Zhou, Haigang Liu, Shumin Yang, Zhenhua Chen, Ying Zou, Bo Sun, Wen Wen, Yong Wang, Xiangzhi Zhang, Renzhong Tai   +15 more
wiley   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Senam Tai Chi dalam Menurunkan Kecemasan Lansia [PDF]

, 2018
Aging is something that can cause health problems, both physical and mental health for the elderly. Anxiety is one of mental health experienced in the elderly.
Diharja, Rohamadi Yuda, Muhith, Abdul, Prabowati, Ririn, Khamida, Khamida   +3 more
core   +2 more sources

PELATIHAN TAI CHI DAN PELATIHAN AI CHI SAMA-SAMA MENINGKATKAN PERFORMA DUAL TASK PADA LANSIA

Sport and Fitness Journal, 2020
Pendahuluan: Aktifitas yang dilakukan seseorang dalam kesehariannya tidak lepas dari aktifitas multitasking dimana pada aktifitas tersebut minimal seseorang harus mampu melakukan dua aktifitas sekaligus (dualtask), lansia dengan gangguan kognitif atau ...
Andy Sirada, I Putu Gede Adiatmika, Muhammad Ali Imron, I Putu Adiartha Griadi, I Made Muliarta, Putu Astawa   +5 more
doaj  

From Displacement to Angle: Diamond‐Based 3D Rotation Sensing for High‐Precision Cellular Force Measurement

Advanced Science, EarlyView.
Cellular forces are traditionally inferred from displacement measurements, which lack rotational information and are constrained by linear model assumptions. This work replaces displacement with rotational angle for the fundamental mechanical readout.
Linjie Ma, Bicong Wang, Tai Nam Yip, Jiahua Zhang, Yicheng Wang, Luyao Zhang, Yong Hou, Yuan Lin, Zhiqin Chu   +8 more
wiley   +1 more source

The Leisure Meaning of Vipassana Activities – Tai-Chi Chuan as an Example

, 2012
[[abstract]]To relieve the heavy pressure of the modern lifestyle, those Vipassana leisure activities, for instance, yoga, meditation, tai-chi, etc., have the function of contemplation of personal physical and mental state, and people pay more attention ...
Chuang, Shu-Min
core  

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source