Results 31 to 40 of about 192,504 (289)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Recognition of HLA-DPB1 alleles and their associated HLA haplotypes in 55 randomized unrelated Taiwanese individuals

open access: yesTzu Chi Medical Journal
OBJECTIVES: Here, we report the distribution of HLA-DPB1 alleles studied in a cohort of 55 randomly collected blood samples from unrelated Taiwanese individuals and the deduced most likely HLA haplotypes associated with the defined DPB1 alleles in the ...
Shee-Ping Chen   +2 more
doaj   +1 more source

從教師認知、教學資源與教學實踐論國語文教育政策之困境與契機 Dilemmas and Opportunities in Mandarin Education Policy Implementation from the Perspectives of Teacher Acknowledgment, Resources, and Practice

open access: yesJournal of Research in Education Sciences, 2020
本研究以12名中學國語文教師為研究對象,就教師認知、教學資源與教學實踐三個面向,進行結構化深度訪談,將所得資料轉譯為口語報告,再進行編碼與歸類分析。期透過教育理想與教育現場兩方對話,對語文教育政策之落實現況更深入理解,並據此提出國語文教育的政策建議。本研究結果顯示:一、教師最關注教師專業,具備高省思與評鑑能力,期待專業成長,盼望將所學轉化運用於課室。不過,教育單位提供的精進課程未能符合需求,在進行時也欠缺適當配套措施,且未能有足夠時間讓教師轉化所學,影響落實的成效。二 ...
陳茹玲 Ju-Ling Chen   +2 more
doaj   +1 more source

The Stoic Monastic: Taiwanese Buddhism and the Problem of Emotions [PDF]

open access: yes, 2006
This paper explores the stoicism of Taiwanese monastics and argues that, in this context, emotions are believed to be dangerous in part because they interfere with spiritual cultivation.
Crane, Hillary
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Efforts to improve the surgical outcome for exotropia and investigation of the insertion locations of the extraocular muscles

open access: yesKaohsiung Journal of Medical Sciences, 2023
In our previous retrospective study, we found that using the strabismus surgery dosages established by western strabismus mentors tends to result in undercorrection of Taiwanese exotropia (XT) patients compared with those in western populations.
Yu‐Hung Lai, Shun‐Jen Chang
doaj   +1 more source

Dairy Product Consumption and Preferences of Polish and Taiwanese Students—NPD Case Study

open access: yesApplied Sciences, 2022
The present study determined the consumption and preferences of dairy products, especially fermented products, in respect of Polish and Taiwanese students, through their answers to seven research questions (RQs) as part of the design process.
Katarzyna Świąder   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Living at the Edge: Religion, Capitalism, and the End of the Nation-State in Taiwan [PDF]

open access: yes, 2000
This is a preprint (author's original) version of an article published in the journal Public Culture in 2000. The final version of this article may be found at http://dx.doi.org/10.1215/08992363-12-2-477 (login may be required)
Weller, Robert
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

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