Results 81 to 90 of about 337,999 (313)

Taiwanese Version of the EQ-5D: Validation in a Representative Sample of the Taiwanese Population

Journal of the Formosan Medical Association, 2007
We know of no validated Taiwanese-language instrument to measure a utility of the patient's health. Our aim was to evaluate the reliability and validity of a Taiwanese version of the EuroQol instrument (EQ-5D) in a Taiwanese population.Questionnaires containing the Taiwanese versions of the EQ-5D and the Short-Form 12 Health Survey (SF-12) were sent to
Ting-Jung Chang, Yen-Huei Tarn, Ching-Lin Hsieh, Wen-Shyong Liou, James W. Shaw, Xue Grace Chiou   +5 more
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Testing the “Epidemiologic Paradox” of Birth Outcomes Among Asian Immigrant Women in Hsin-Chu County, Taiwan

Journal of the Formosan Medical Association, 2008
Taiwan saw an increase in immigration during the last decade. This retrospective study investigated whether immigrant status confers a protective effect on birth outcomes and whether this effect varies across racial/ethnic subgroups in Hsin-Chu County ...
Ching-Yun Liu, Nien-Tzu Chang, Pesus Chou   +2 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

The effects of integrated osteoporosis education on osteoporosis knowledge, attitude, behavior and quality of life among middle-aged and elderly osteoporosis patients

Osteoporosis and Sarcopenia, 2023
I-Chin Huang, Chih-Lung Lin, Hsiu-Hung Wang   +2 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Clay mineral composition and their sources for the fluvial sediments of Taiwanese rivers

, 2012
Located at the collision boundary between the Philippine Sea Plate and the Eurasian Continental Plate, the island of Taiwan is generally recognized as an important example in the MARGINS Program Science Plan and “source-to-sink” research because of its ...
Chuanshun Li, Xuefa Shi, S. Kao, Min‐Te Chen, Yanguang Liu, Xisheng Fang, Huahua Lü, J. Zou, Shengfa Liu, S. Qiao   +9 more
semanticscholar   +1 more source

Application of deep learning algorithm to detect and visualize vertebral fractures on plain radiographs

Osteoporosis and Sarcopenia, 2023
Hsuan-Yu Chen, Christina Soong, Feng-Huei Lin, Tsung-Han Yang, Ding-Cheng Chan, Chih-Hao Chang, Rong-Sen Yang   +6 more
doaj   +1 more source