Results 51 to 60 of about 131 (88)

Baseline Anti-Dengue IgG Seroprevalence in a Pediatric Brazilian Population Before TAK-003 Vaccination

The American Journal of Tropical Medicine and Hygiene
ABSTRACT. Dengue remains a major public health challenge in Brazil, with recurrent outbreaks placing a strain on healthcare systems. The TAK-003 vaccine offers a promising control strategy, particularly for children. This cross-sectional study evaluated the seroprevalence of anti-dengue IgG in 643 children and adolescents aged 4–16 ...
Bortuluzi, Amanda Maria Miguel, dos Santos, Paulo César Pereira, Anschau, Luana Clemm Kuhnen, da Silva Santos, Andrea, Tsuha, Daniel, Santos, Devanildo de Souza, de Souza, William M., de Oliveira, Roberto Dias, Croda, Julio   +8 more
openaire   +2 more sources

Dengue dynamics: A holistic predictive model considering epidemic, vaccination, and environmental factors

Global Public Health
This research applied a predictive model to analyse the role that vaccination and community factors play in controlling the dengue virus. The study considers epidemiological and environmental data from the city of São Paulo (Brazil) after the start of ...
Wenru Wang, Hilal Atasoy, Yao Yao, Miklos Vasarhelyi, Henrique Tajiri, Fabricia Silva da Rosa, Ana Carolina da Costa, Gabriel Donadio Costa, Rogério João Lunkes, Vladimir Arthur Fey, Dayanni Nogueira Castro, Katiane Rodrigues Torres   +11 more
doaj   +1 more source

The pre- and post-COVID-19 pandemic dengue fever patterns in southeastern coastal China in 2019 and 2024: molecular evolution and strain replacement

Frontiers in Microbiology
BackgroundThe evolutionary dynamics of dengue virus type 1 (DENV-1) in non-endemic settings such as southeastern coastal China where outbreaks predominantly stem from imported cases, remains insufficiently defined, particularly in relation to lineage ...
Tianran Zhang, Yaqi Shi, Leyi Zhang, Jian Wang, Chengchao Yu, Binbin Lv, Sisi Wu, Yiru Huang, Xuewei Liu, Hupiao Dai, Mingshi Zhou, Yanjuan Liao, Wei Wang, Guankai Lin   +13 more
doaj   +1 more source

Operational challenges and lessons learned from conducting febrile surveillance in a long-term randomized dengue vaccine trial in Latin America and Asia-Pacific

Travel Medicine and Infectious Disease
Background: In trials, dengue vaccine efficacy evaluation relies on participants presenting with febrile illness/clinically suspected dengue contacting the study site for sample collection and clinical assessment within a short timeframe.
Harald Pfaar, Eduardo López-Medina, Ian Escudero, Yanee Hutagalung, Nicholas Roubinis, Seloni Thakrar, Charissa Fay Corazon Borja-Tabora, Vianney Tricou, Suely Tuboi   +8 more
doaj   +1 more source

Impact of TAK-003 on epidemiologic, economic and quality-of-life burden of dengue: comparison of the results from a dynamic transmission model and a static model with a dynamic component

International Journal of Infectious Diseases
Introduction: Dynamic transmission models are commonly used to evaluate the impact of vaccination as they capture both direct and indirect effects; however, they tend to be complex and computationally intensive.
Elizaveta Kharitonova, Dr Jing Shen, Anna Tytula, Justyna Zawieja, Yaneth Gil Rojas, Samuel Aballea, Riona Hanley   +6 more
doaj   +1 more source

Refining uncertainty about the TAK-003 dengue vaccine with a multi-level model of clinical efficacy trial data

Abstract Background A safe and effective vaccine that can be universally administered would represent a major advance in efforts to control dengue. Takeda’s TAK-003 is a potential candidate for such a vaccine. However, phase-III trial results suggest that TAK-003 confers differential protection by outcome, serotype, and ...
Manar Alkuzweny, Guido España, T Alex Perkins   +2 more
openaire   +2 more sources

TAK-003 dengue vaccine – a new hope for safe travel to endemic areas: efficacy, safety and future perspectives

Medicine and Public Health
Background: Dengue fever remains a major health risk, with 100 to 400 million clinical cases occurring each year. TAK-003 a tetravalent live-attenuated vaccine, offers potential protection against all four dengue virus (DENV) serotypes (DENV-1, DENV-2, DENV-3, DENV-4), providing a new option for travelers to dengue-endemic areas.
Sikora, Agnieszka Weronika, Stopyra, Lidia   +1 more
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Opportunities and challenges of mRNA technologies in development of dengue virus vaccine

Frontiers in Immunology
Dengue virus (DENV) is a mosquito-borne virus with a significant human health concern. With 390 million infections annually and 96 million showing clinical symptoms, severe dengue can lead to life-threatening conditions like dengue hemorrhagic fever (DHF)
Xiaoyang Liu
doaj   +1 more source

Adverse Events and Immunization Errors Following a Mass Immunization Campaignwith TAK‐003 in Dourados, Brazil: A Post‐Marketing Safety Surveillance Analysis

Journal of Medical Virology
ABSTRACT This descriptive observational study based on post‐marketing surveillance data evaluates adverse events following immunization (AEFI) associated with the TAK‐003 (Qdenga®) vaccine. Conducted in Dourados, Brazil, between January and November 2024, the study aimed to assess the frequency, nature, and severity of AEFI to inform ...
Luana Clemm Kuhnen Anschau, Amanda Maria Miguel Bortuluzi, Andrea da Silva Santos, Devanildo de Souza Santos, Sandra de Souza Rodrigues, Indianara Ramires Machado, Renato de Ávila Kfouri, Marco Aurélio Palazzi Sáfadi, Roberto Dias de Oliveira, Julio Croda   +9 more
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Segurança e Eficácia da Vacina Qdenga® (TAK-003) em Crianças de Até 12 anos

Brazilian Journal of Implantology and Health Sciences
Introdução: A dengue, uma doença viral transmitida pelo mosquito Aedes aegypti, representa um desafio significativo para a saúde pública, especialmente no Brasil, onde ocorre uma epidemia. A vacina Qdenga (TAK-003) surge como uma promissora intervenção, considerando sua segurança e eficácia potencial.
Gabriel dos Santos Medeiros, Ana Caroliny Suassuna de Aquino, Erinaldo De Almeida Pinto Júnior, Luiz Antônio Barbosa de Figueiredo Medeiros, Lucas Matheus Formiga Farias, Ruthy Anny Mendes Dantas, Henrique Jorge Rebouças Júnior, Bárbara Maria Oliveira Bitencourt Nóbrega, Ana Luísa Moreira Barreiro de Araújo, Karolainy Formiga da Silva, Neidivânia Medeiros da Nóbrega, Maria Izadora de Caldas Francelino, Milena Nunes Alves de Sousa   +12 more
openaire   +1 more source