Results 61 to 70 of about 1,260,322 (393)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Association of incidence of colorectal polyp with markers of insulin resistance and other related factors: a cross-sectional study

Scientific Reports
To explore the relationship between the incidence of colorectal polyps and related factors such as markers of insulin resistance (IR) ,  a retrospective analysis was used to collect 2716 patients who underwent physical examinations in Guangzhou Cadre and
Yan Xu, Hongzhen He, Zhanhui Ye, Siquan Li, Hu Li, Xiaojuan Wang, Weizheng Zhang, Na Liu, Xiangsheng Cai   +8 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Labour mobility as part of the solution

Forced Migration Review, 2016
While refugee families lack access to work and struggle to survive, there are skills gaps around the world that could benefit from skilled refugees’ talents. Developing a system for refugees to be able to compete for international jobs with multinational
Sayre Nyce, Mary Louise Cohen, Bruce Cohen   +2 more
doaj  

Agent-based multimodal information extraction for nanomaterials

npj Computational Materials
Automating structured data extraction from scientific literature is a critical challenge with broad implications across domains. We introduce nanoMINER, a multi-agent system combining large language models and multimodal analysis to extract essential ...
R. Odobesku, K. Romanova, S. Mirzaeva, O. Zagorulko, R. Sim, R. Khakimullin, J. Razlivina, A. Dmitrenko, V. Vinogradov   +8 more
doaj   +1 more source

First-generation students’ identity compatibility, sense of belonging and self-efficacy going to and through honors talent programs: a mixed-method study

International Journal of Educational Research Open
When examining enrollment and graduation grades, higher education remains less accessible for first-generation students. Dutch first-generation students are also less likely to attend honors talent programs.
Annegien Langeloo, Elanor Kamans
doaj   +1 more source

Predictive Competences of High-potential Talent Employees

Journal of Work and Organizational Psychology, 2023
In talent management, predicting high potential (HP) is one of the most important questions human resources professionals face. The main goal of this study was to analyze which competences predict employees’ HP and whether these competences differ by ...
José M. de Haro, Mariano García-Izquierdo, Ana Castaño, Antonio L. García-Izquierdo   +3 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Towards greater visibility and recruitment of skilled refugees

Forced Migration Review, 2018
Showcasing refugees’ skills connects refugees to global work opportunities, and also shifts the narrative from one of refugees being burdens to host countries to one in which refugees are recognised as skilled workers for whom countries should be ...
Leah Nichles, Sayre Nyce
doaj  

A study on the correlation of thyroid nodules with METS-IR and SII in a population undergoing health checkups

Frontiers in Endocrinology
ObjectiveTo investigate the associations between thyroid nodules and two emerging biomarkers-Metabolic Score for Insulin Resistance (METS-IR) and Systemic Immune-Inflammation Index (SII)-in adults undergoing routine health checkups.MethodsIn this ...
Ruoping Guan, Guokui Dai, Chuanjiang Ye, Xiangsheng Cai   +3 more
doaj   +1 more source