Results 51 to 60 of about 1,025,126 (312)

‘You don’t need influence … all you need is your first opportunity!’: The Early Broadcast Talent Show and the BBC [PDF]

open access: yes, 2014
Popular histories of the reality talent show often position programmes like Opportunity Knocks as key generic precursors to the popular formats of today.
Holmes, Su
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

TALENT AND TALENT IN THE SPORT OF ATHLETICS!

open access: yes, 2023
This article analyzes the results of young talents in athletics at a young age and the results they showed when they were older. Also, data on the scientific development of sports results were studied.
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

The causes and impact of business failure among small to micro and medium enterprises in South Africa

open access: yesAfrica’s Public Service Delivery & Performance Review, 2019
Background: Over 70% of small to micro and medium enterprises (SMMEs) in South Africa fold within the first 5–7 years of inception and there is generally no agreement among scholars and experts as to why this is so. Aim: This study conducts an empirical
Bernard Bushe
doaj   +1 more source

Organisation Change Plan: Getting Started [PDF]

open access: yes, 2019
[Excerpt] The vision of the program is the establishment of a capability within the organisation to attract, recruit, on-board and sustain talent from people on the autism spectrum. Why is this important? As we know we are in a war for talent to fuel our
DXC Technology
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Defining student success as a multidimensional concept: A scoping review

open access: yesInternational Journal of Educational Research Open
Student success is a critically important concept in educational assessment and research, yet a comprehensive synthesis of its defining elements remains absent.
Jorien Vugteveen   +2 more
doaj   +1 more source

Organisation Change Plan [PDF]

open access: yes, 2019
[Excerpt] The vision of the program is the establishment of a capability within the organisation to attract, recruit, on-board and sustain talent from people on the autism spectrum. Why is this important? As we know we are in a war for talent to fuel our
DXC Technology
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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