Results 51 to 60 of about 122,300 (266)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Organizational Unlearning: A Bibliometric Study and Visualization Analysis Via CiteSpace
SAGE OpenCoping with evolution and the changes it brings to the workplace remains a major concern for organizational leaders. This study explores the hotspots, trends, and future directions of the field of organizational unlearning to complement the extant ...
Jiang Chen +2 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Crossing Boundaries, Creating Change: A Competence Framework for Bridge-Builders
Baltic Journal of Sport and Health SciencesPurpose: This study aims to develop a comprehensive competence framework for professionals facilitating cross-sector collaboration, innovation, and systemic change across organisational, disciplinary, and cultural boundaries. It addresses the current gap
Robert Ovbiagbonhia +3 more
doaj +1 more source
Talent Management: From Talent Retention To Talent Optimization
İlköğretim Online, 2023 Human resource managers all across the world have come to understand that "Talented Employees construct a company and are the gates to success" and are working through the night to develop tactics to achieve this. The abilities and skills of the workforce determine a company's destiny by giving it a competitive advantage over rivals.
openaire +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
B3Emo: Quantifying Affect as a Double-Edged Sword in Strategic LLM Interactions
IEEE AccessThe deployment of large language models (LLMs) in interactive roles such as automated negotiators, customer service agents, and strategic partners requires them to handle not only logical tasks but also the socio-emotional dimensions of interaction.
Aleksei Stepin +12 more
doaj +1 more source