Results 31 to 40 of about 122,068 (266)

Association of incidence of colorectal polyp with markers of insulin resistance and other related factors: a cross-sectional study

Scientific Reports
To explore the relationship between the incidence of colorectal polyps and related factors such as markers of insulin resistance (IR) ,  a retrospective analysis was used to collect 2716 patients who underwent physical examinations in Guangzhou Cadre and
Yan Xu, Hongzhen He, Zhanhui Ye, Siquan Li, Hu Li, Xiaojuan Wang, Weizheng Zhang, Na Liu, Xiangsheng Cai   +8 more
doaj   +1 more source

A comparison of cemented and cementless intra-neck curved stem use during hip-preserving reconstruction following massive femoral malignant tumor removal

Frontiers in Oncology, 2022
BackgroundPatients who undergo massive femoral malignant tumor (MFMT) resection often exhibit shortened femoral metaphyseal juxta-articular segments. The use of a customized femoral endoprosthesis (CFE) with an intra-neck curved stem (INCS) has emerged ...
Qi You, Qi You, Minxun Lu, Minxun Lu, Li Min, Li Min, Yi Luo, Yi Luo, Yuqi Zhang, Yuqi Zhang, Yitian Wang, Yitian Wang, Chuanxi Zheng, Chuanxi Zheng, Yong Zhou, Yong Zhou, Chongqi Tu, Chongqi Tu   +17 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Towards greater visibility and recruitment of skilled refugees

Forced Migration Review, 2018
Showcasing refugees’ skills connects refugees to global work opportunities, and also shifts the narrative from one of refugees being burdens to host countries to one in which refugees are recognised as skilled workers for whom countries should be ...
Leah Nichles, Sayre Nyce
doaj  

A study on the correlation of thyroid nodules with METS-IR and SII in a population undergoing health checkups

Frontiers in Endocrinology
ObjectiveTo investigate the associations between thyroid nodules and two emerging biomarkers-Metabolic Score for Insulin Resistance (METS-IR) and Systemic Immune-Inflammation Index (SII)-in adults undergoing routine health checkups.MethodsIn this ...
Ruoping Guan, Guokui Dai, Chuanjiang Ye, Xiangsheng Cai   +3 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Unveiling the Absence of a Local Medical Device and Biomaterials Manufacturing Industry in Zimbabwe: A Literature Review

Health Technology Assessment in Action, 2023
Medical devices and biomaterials play pivotal roles in the provision of healthcare and advancements in medicine. Zimbabwe, a low-income country in Southern Africa, faces resource constraints while combating both communicable and non-communicable diseases,
Mthabisi Talent George Moyo
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Reframing talent development in the intelligence age: reasoning from first principles

Frontiers in Psychology
This perspective paper examines how AI is reshaping talent management in the emerging intelligence age, where value creation depends on the ability to interpret, apply, and scale insight. Despite advances in talent analytics, learning, and skills models,
Ederick Stander, Ederick Stander, Ian Rothmann, Carla du Plessis, Sibusiso Mnxuma, Sibusiso Mnxuma, Jordan Roothman, Joe Watson, Vesselin Popov   +8 more
doaj   +1 more source