Results 61 to 70 of about 122,300 (266)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Effects of Antisense Oligonucleotides Against miRNA-21 on Growth of Human Colon Cancer Cells in vivo

Zhongliu Fangzhi Yanjiu, 2019
Objective To investigate the effect of antisense oligonucleotides(ASOs) against miR-21 expression on the growth of human colon carcinoma cells line HCT116 in vivo.
LIU Shiming, CUI Panpan, DING Tao, CHEN Chao, GUO Mengmeng, XU Lin   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The efficacy of the use of ZiG money as a sole legal tender in Zimbabwe. The case of Chinhoyi Town, Zimbabwe.

The Dyke
To decide on the acceptability and usability of ZiG on the Zimbabwean market, the paper traces the history of the use of the local currencies and the operation of the Reserve Bank of Zimbabwe’s monetary policy dating back to 1980.
Timothy Matinhure, Talent Gwedavi
doaj   +1 more source

Effects of NDUFA4 Overexpression on Growth of Human Colon Cancer Cells in vitro

Zhongliu Fangzhi Yanjiu, 2019
Objective To investigate the effects of NDUFA4 overexpression on the growth of human colon cancer cells in vitro and to explore its potential mechanism. Methods The recombinant plasmid p-NDUFA4 (p-NDUFA4) and the control plasmid (p-Cont) were transiently
LIU Shiming, DING Tao, LEI Liangyu, HU Lin, MAO Ling, CHEN Chao, GUO Mengmeng, XU Lin   +7 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Effective student engagement with blended learning: A systematic review

Heliyon
Although student engagement is known to promote learning outcomes in higher education, what elements of blended learning designs impact effective student engagement and hereby learning outcomes, has not been clarified yet.
M. De Bruijn-Smolders, F.R. Prinsen
doaj   +1 more source

Application of Biosensors in Non-invasive Blood Glucose Monitoring [PDF]

E3S Web of Conferences
Blood glucose monitoring is essential for managing conditions like diabetes and liver dysfunction, with a growing need among various population groups, including the elderly, pregnant, and individuals engaging in specific dietary and exercise regimes ...
Zhang Huaiyue
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From Abstract to Domain-Specific: Development and Validation of Matrix Reasoning Tasks for Students in Biology

Journal of Intelligence
Matrix reasoning tests are frequently used to measure intelligence and identify gifted students across domains. To date, there is limited evidence on the usefulness of contextualised tasks for identifying domain-specific giftedness. In the current study,
Colin Peperkorn, Claas Wegner
doaj   +1 more source