Results 81 to 90 of about 1,260,322 (393)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Effects of NDUFA4 Overexpression on Growth of Human Colon Cancer Cells in vitro

Zhongliu Fangzhi Yanjiu, 2019
Objective To investigate the effects of NDUFA4 overexpression on the growth of human colon cancer cells in vitro and to explore its potential mechanism. Methods The recombinant plasmid p-NDUFA4 (p-NDUFA4) and the control plasmid (p-Cont) were transiently
LIU Shiming, DING Tao, LEI Liangyu, HU Lin, MAO Ling, CHEN Chao, GUO Mengmeng, XU Lin   +7 more
doaj   +1 more source

Talent Development in Achievement Domains: A Psychological Framework for Within- and Cross-Domain Research

Perspectives on Psychological Science, 2020
Achievement in different domains, such as academics, music, or visual arts, plays a central role in all modern societies. Different psychological models aim to describe and explain achievement and its development in different domains.
F. Preckel, Jessika Golle, R. Grabner, Linda Jarvin, Aaron Kozbelt, Daniel Müllensiefen, P. Olszewski-Kubilius, W. Schneider, R. Subotnik, Miriam Vock, F. Worrell   +10 more
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Global Talent Management and Performance in Multinational Enterprises: A Multilevel Perspective

Journal of Management, 2018
The link between global talent management (GTM) and multinational enterprises’ (MNEs) performance has not been theorized or empirically tested. We develop a theoretical framework for how GTM links to performance at the headquarters (HQ), subsidiary, and ...
D. Collings, Kamel Mellahi, Wayne F. Cascio   +2 more
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Defining student success as a multidimensional concept: A scoping review

International Journal of Educational Research Open
Student success is a critically important concept in educational assessment and research, yet a comprehensive synthesis of its defining elements remains absent.
Jorien Vugteveen, Fabiola Figueroa Esquivel, Claudia Luijer   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Application of Biosensors in Non-invasive Blood Glucose Monitoring [PDF]

E3S Web of Conferences
Blood glucose monitoring is essential for managing conditions like diabetes and liver dysfunction, with a growing need among various population groups, including the elderly, pregnant, and individuals engaging in specific dietary and exercise regimes ...
Zhang Huaiyue
doaj   +1 more source

Nurturing talent through curriculum integration [PDF]

, 2007
In this paper I discuss the benefits of curriculum integration for gifted and talented students in the regular classroom setting. Although this approach to curriculum delivery enhances learning for all learners, the focus of this article is the gifted ...
Brough, Chris Jane
core   +1 more source