Results 101 to 110 of about 94,805 (348)

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Spatial-Temporal Distribution Characteristics and Influencing Factors of High-Level Tennis Players in China

Redai dili
With the vigorous development of the global sports industry and the continuous improvement of competitive sports, the cultivation and development of sports talent has become an important component of sports strategies in various countries.
Chen Kunlun, Han Zeyu, Zhang Yu, Chu Pengfei   +3 more
doaj   +1 more source

Reform and Practice of Talent Cultivation Model of Food Engineering Based on “Excellence Program” in Perspective of Integration of Industry and Education [PDF]

, 2018
Chao Li, Weidong Wang
openalex   +1 more source

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Are geographical indications a way to "decommodify" the coffee market? [PDF]

, 2008
The commodity nature of green coffee is the main cause of "the coffee paradox" (decreasing prices at production level and rising prices at consumption level).
Belletti, Giovanni, Galtier, Franck, Marescotti, Andrea   +2 more
core  

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Exploration and practice of the teaching model for compound talent education based on the background of digital economy [PDF]

MATEC Web of Conferences
In the era of digital economy, enterprises are increasingly focusing on new demands, and the integration of new technologies and new business models is advancing together.
Su Qinqin
doaj   +1 more source

Innovative Strategies for Talent Cultivation in New Ventures Under Higher Education. [PDF]

Front Psychol, 2022
Liao S, Zhao C, Chen M, Yuan J, Zhou P.
europepmc   +1 more source

Computational Evidence that Self-regulation of Creativity is Good for Society [PDF]

, 2014
Excess individual creativity can be detrimental to society because creators invest in unproven ideas at the expense of propagating proven ones. Moreover, a proportion of individuals can benefit from creativity without being creative themselves by copying
Gabora, Liane, Tseng, Simon
core  

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source