Results 51 to 60 of about 94,805 (348)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui   +14 more
wiley   +1 more source

Cultivating big data talent by combing various disciplines and utilizing multiple resources

open access: yes大数据, 2016
Rapid development of big data science and technology put forward great challenges to talent cultivation.Data scientist should have the capability of coax commercial value from tremendous data and require multi-disciplinary training.Based on the progress ...
Libo WU
doaj  

Satisfaction with talent cultivation, evaluation, and incentive mechanisms among staff at China′s provincial, municipal, and county-level CDCs: an online survey

open access: yesZhongguo gonggong weisheng
ObjectiveTo understand the satisfaction and suggestions of center for disease control and prevention (CDC) personnel at the provincial, city, and county levels in China regarding current talent cultivation, evaluation, and incentive mechanisms, and to ...
Chunhua ZHANG   +4 more
doaj   +1 more source

Research on Cultivation Mode of Engineering Practical Ability Based on Post Simulation – Taking the hydrology and water resources engineering major in Tianjin Agricultural University as the example

open access: yesSHS Web of Conferences, 2015
This article aims at exploring the cultivation mode of engineering practical abstract based on post simulation to provide scientific and reasonable basis for talent cultivation.
Wang Lizhen, Sun Shuhong, Liu Ling
doaj   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

open access: yesAdvanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang   +16 more
wiley   +1 more source

D’Holbach on (Dis-)Esteeming Talent

open access: yesJournal of Modern Philosophy, 2020
Rousseau argues that holding the talented in high public esteem leads the less talented to esteem their natural virtues less highly and therefore to neglect the cultivation of these virtues.
Andreas Blank
doaj   +4 more sources

Receptivity to Mystery: Cultivation, Loss, and Scientism [PDF]

open access: yes, 2012
The cultivation of receptivity to the mystery of reality is a central feature of many religious and philosophical traditions, both Western and Asian. This paper considers two contemporary accounts of receptivity to mystery – those of David E.
Kidd, Ian James
core  

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

open access: yesAdvanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch   +4 more
wiley   +1 more source

Evaluation and spatiotemporal evolution of veterinary talent competitiveness: a new perspective of veterinary education

open access: yesFrontiers in Veterinary Science
IntroductionImproving the quantity and quality of veterinary talent cultivation is an urgent issue to address in current veterinary education and is key to enhancing veterinary talent competitiveness.
Xianhang Xu   +4 more
doaj   +1 more source

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