Results 71 to 80 of about 42,896 (250)

Clarifying TID and TD in sport: an integrative phase-based framework of talent assessment and promotion

Frontiers in Psychology
Research on Talent Identification (TID), and Talent Development (TD) in sport has produced a diverse body of theoretical frameworks, empirical findings, and practice-oriented models addressing different aspects of long-term athlete development.
Fabienne Döringer, Mark Pfeiffer
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Talent identification transparency: an alternative perspective [PDF]

, 2018
Over the course of the last decade, talent management has attracted a great deal of attention in the academic literature. Even though the field has evolved, much scepticism continues to surround it, and many questions are still to be answered that may ...
Vaiman, Vlad, Kostanek, Edyta, Khoreva, Violetta   +2 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Talent identification and recruitment in youth soccer: Recruiter's perceptions of the key attributes for player recruitment.

PLoS ONE, 2017
Using the modified Delphi method, we aimed to understand the attributes youth coaches and recruiters perceive as important when identifying skilled youth performance at the entry level of representative soccer in Australia (i.e., Under 13 years ...
Paul Larkin, Donna O'Connor
doaj   +1 more source

How similarities and differences between sports lead to talent transfer : a process approach

, 2020
In this chapter, we argue that talent transfer is not only possible as a classical product-oriented approach, but also as a process approach. To successfully transfer from one sport to another, it is important to determine the underlying performance ...
Schorer, Jörgeditor, Baker, Josepheditor, Lenoir, Matthieu, Cobley, Stepheneditor, Pion, JohanGE300001111006658010007910130000-0002-2633-9120F9990BEA-F0ED-11E1-A9DE-61C894A0A6B4, Teunissen, Jan Willem, Spruijtenburg, Gwennyth, ter Welle, Stijn, Faber, Irene   +8 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A systematic review of female badminton talent identification: Implications for development

Sport TK
This study aimed to systematically review female badminton talent identification methods and their implications for athlete development. The review analysed literature on talent identification criteria, including physiological, psychological, and social
Amat Komari, Rezha Arzhan Hidayat, Fadli Ihsan, Muhammad Wahyu Arga, Ari Iswanto, Norsilawati binti Abdul Razak   +5 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source