Results 71 to 80 of about 294,658 (302)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Annals of Applied Sport Science, 2013 Talent identification and training the athletes of the basic levels in track and field requires codifying a proper model like any other system so that any duplication is prevented as well as knowing the right path.
Ebrahim Ghasemzadeh Mirkolaee +2 more
doaj
Development of a sprinter talent identification model in children aged 10–12 years
Sport TKThis study aimed to develop a talent identification model for sprinters based on anthropometric components, physical qualities, and biomotor abilities in children aged 10–12 years. A research and development model was employed.
Ananda Perwira Bakti +3 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Network-based ranking in social systems: three challenges [PDF]
, 2020 Ranking algorithms are pervasive in our increasingly digitized societies, with important real-world applications including recommender systems, search engines, and influencer marketing practices.
Lü, Linyuan, Mariani, Manuel S.
core +2 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The Center for Talented Youth Identification Model: A Review of the Literature [PDF]
, 2011 This paper reviews the literature on the Talent Search identification model that was developed by Julian Stanley as the Study of Mathematically Precocious Youth at Johns Hopkins in the 1970s and implemented by the Center for Talented Youth from the ...
Tourón, J. (Javier) +1 more
core
Optimising the learning of gifted aboriginal students [PDF]
, 2006 [Abstract]: According to the United Nations Educational, Scientific and Cultural Organisation's (2000) 'Education for All' goals, all students are entitled to opportunities to fulfil their potential.
Garvis, Susanne
core +2 more sources
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Are youth sport talent identification and development systems necessary and healthy?
Sports Medicine - Open, 2018 Talent identification and development systems (TIDS) are commonly used in professional sport to convert youth athletes into sporting stars of the future.
Fieke Rongen +3 more
doaj +1 more source