Results 61 to 70 of about 13,745 (260)

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK pathways

Arthritis &Rheumatology, Accepted Article.
Introduction Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source

Multi‐omic profiling reveals immune cell priming signature linked to lupus prognosis

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is a multi‐organ disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

Novel application of gamification to support undergraduate anatomy: Student perceptions and performance

Anatomical Sciences Education, EarlyView.
Abstract Anatomy is a foundational component of various medical and paramedical disciplines. Existing research has suggested that games or game elements can improve student interest in musculoskeletal (MSK) anatomy. This project builds on previous gamification and serious game work and incorporates new anatomy‐based games into undergraduate anatomy ...
Emmeline Berger, Jacqueline Carnegie, Christopher J. Ramnanan   +2 more
wiley   +1 more source

Mixed Evidence for Impact of Early Infant Gut Microbiome and Later Development of Autism Spectrum Disorder in the MARBLES Prospective Cohort Study

Autism Research, EarlyView.
ABSTRACT This study investigated the relationship between early infant gut microbiome composition and subsequent neurodevelopmental outcomes. Fecal samples from children in the markers of autism risks in babies‐learning early signs (MARBLES) study, a cohort with elevated likelihood of autism, were collected between 0 and 7 months of age and analyzed ...
Jennie Sotelo‐Orozco, Diana H. Taft, Jassim Al‐Oboudi, Brittany C. Baikie, Cailyn Lake, Meghan Miller, David A. Mills, Daniel J. Tancredi, Rebecca J. Schmidt, Irva Hertz‐Picciotto, Deborah H. Bennett   +10 more
wiley   +1 more source

Ankle joint replacement for necrosis of the talus, crusarthrosis, equinovarus and adducted foot

Гений oртопедии
Introduction Surgical treatment of patients with avascular osteonecrosis of the talus and post-traumatic hindfoot deformity is associated with high morbidity, difficulty of early disease detection, the discrepancy between patient expectations and ...
Vasily V. Kuznetsov, Victor G. Protsko, Sargon K. Tamoev, Stanislav A. Osnach, Alexey V. Mazalov, Valery V. Platonov   +5 more
doaj   +1 more source

Why do people choose to enter and exit the teaching profession? An interdisciplinary quantitative synthesis

British Educational Research Journal, EarlyView.
Abstract Many nations experience recurring shortages of teachers in particular subjects, prompting concerns that pupils' education is suffering as a result. Researchers have responded by generating a sizable literature on the reasons for which people enter and exit the teaching profession.
Sam Sims, Harriet Lowes‐Belk, Clare Routledge   +2 more
wiley   +1 more source

Re‐thinking teachers' professional development: An analysis of National Professional Qualifications for school leaders in England

British Educational Research Journal, EarlyView.
Abstract This article considers how teachers' professional development could be redeveloped to help address the current crisis in teacher recruitment and retention by offering greater intellectual rigour and more opportunities for intellectual growth. Our analysis is focused on the UK government's current policy for leadership development in schools in
Mark Innes, Elizabeth Gregory, Louisa Dawes   +2 more
wiley   +1 more source

Does education policy affect teachers' learning needs? An international comparison of trends in teachers' continuing professional learning needs in secondary schools in Australia, England, Japan and the Netherlands

British Educational Research Journal, EarlyView.
Abstract Education policy changes are believed to influence teachers' continuing professional learning (CPL) needs, but there is limited empirical evidence to support these claims. This lack of deep understanding has significant practical implications. This study used a new circular conceptual framework to analyse teachers' CPL needs. Leveraging public
Rikkert M. van der Lans, Remmert Daas, Joost Jansen in de Wal, Elaine Wilson, Noriyuki Inoue, Tracy L. Durksen, Frank Cornelissen   +6 more
wiley   +1 more source

Subterranean environments contribute to three‐quarters of classified ecosystem services

Biological Reviews, EarlyView.
ABSTRACT Beneath the Earth's surface lies a network of interconnected caves, voids, and systems of fissures forming in rocks of sedimentary, igneous, or metamorphic origin. Although largely inaccessible to humans, this hidden realm supports and regulates services critical to ecological health and human well‐being.
Stefano Mammola, David Brankovits, Tiziana Di Lorenzo, Isabel R. Amorim, Raluca Ioana Bancila, Adrià Bellvert, Enrico Bernard, Anna Blomberg, Paulo A.V. Borges, Martina Cappelletti, Rodrigo Lopes Ferreira, Rosalina Gabriel, Diana M. P. Galassi, Laura Garzoli, Vasilis Gerovasileiou, Grant C. Hose, Kathryn L. Korbel, Simone Martino, Ana Z Miller, Nataša Mori, Veronica Nanni, Giuseppe Nicolosi, Mattia Saccò, Troy S. Sakihara, Marconi Souza Silva, Anne E. Tamalavage, Maja Zagmajster, Efraín Chávez, Christian Griebler, Pedro Cardoso, Alejandro Martínez   +30 more
wiley   +1 more source

High-Resolution Detection of Periglacial Landforms Deformation Using Radarsat-2 and GF-7 Stereo Optical Imagery

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
In cold mountain environments, rock glaciers and talus represent common periglacial landforms. Accurate monitoring of their activity is crucial for understanding alpine kinematics.
Xuefei Zhang, Min Feng, Tao Li, Jiyi Chen, Decai Jiang, Jinhao Xu, Dezhao Yan, Xiaoqing Zhou, Xiang Zhang, Jing Lu   +9 more
doaj   +1 more source