Results 21 to 30 of about 23,707 (206)

Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma

Cancer Biology & Medicine, 2021
Objective: Glioma is a highly invasive tumor, frequently disposed in essential areas of the brain, which makes its surgical excision extremely difficult; meanwhile adjuvant therapy remains quite ineffective.
Evgeniya V. Dolgova, Oleg M. Andrushkevich, Polina E. Kisaretova, Anastasia S. Proskurina, Genrikh S. Ritter, Tatyana D. Dubatolova, Margarita V. Romanenko, Oleg S. Taranov, Yaroslav R. Efremov, Evgeniy L. Zavyalov, Alexandr V. Romaschenko, Sergey V. Mishinov, Svetlana S. Kirikovich, Evgeniy V. Levites, Ekaterina A. Potter, Alexandr A. Ostanin, Elena R. Chernykh, Stanislav Yu. Roshchin, Anatoliy V. Bervitskiy, Galina I. Moysak, Jamil A. Rzaev, Sergey S. Bogachev   +21 more
doaj   +1 more source

Fullerenol Quantum Dots-Based Highly Sensitive Fluorescence Aptasensor for Patulin in Apple Juice

Toxins, 2022
A highly selective and sensitive aptasensor for detecting patulin (PAT) was constructed based on the fluorescence quenching of fullerenol quantum dots (FOQDs) towards carboxytetramethylrhodamine (TAMRA) through PET mechanism. The π-π stacking interaction
Hua Pang, Hui Li, Wen Zhang, Jin Mao, Liangxiao Zhang, Zhaowei Zhang, Qi Zhang, Du Wang, Jun Jiang, Peiwu Li   +9 more
doaj   +1 more source

Selenomethionine as alternative label to the fluorophore TAMRA when exploiting cell-penetrating peptides as blood-brain barrier shuttles to better mimic the physicochemical properties of the non-labelled peptides.

European Journal of Pharmaceutical Sciences, 2023
The cell-penetrating peptides (CPPs) Tat and penetratin are frequently explored as shuttles for drug delivery across the blood-brain barrier (BBB). CPPs are often labelled with fluorophores for analytical purposes, with 5(6)-carboxytetramethylrhodamine ...
Dagmar Ýr Þorgeirsdóttir, J. H. Andersen, Marcus Perch-Nielsen, L. Møller, Freja Grønbæk-Thorsen, H. G. Kolberg, B. Gammelgaard, M. Kristensen   +7 more
semanticscholar   +1 more source

A novel dual-labeled small peptide as a multimodal imaging agent for targeting wild-type EGFR in tumors.

PLoS ONE, 2022
The epidermal growth factor receptor (EGFR) is over-expressed in various human cancer. The over-expression of EGFR in tumors is an excellent target for the development of cancer imaging agents. In the present study, we developed Tc-99m SYPIPDT-GHEG-ECG-K-
Myoung Hyoun Kim, Seul-Gi Kim, Dae-Weung Kim   +2 more
doaj   +1 more source

Amrutikarana of Ayurvedic metallic preparations: A systemic review

Journal of Ayurveda, 2022
Objectives: Ayurvedic metallic preparations are always a concern for the safety issue. A special process was also designed in the ancient classics of Rasashastra to remove the blemishes of such metallic preparation known as Amrutikarana.
Om Pandey, Prashant Bedarkar, Biswajyoti Patgiri   +2 more
doaj   +1 more source

A Colorimetric Aptasensor for Ochratoxin A Detection Based on Tetramethylrhodamine Charge Effect-Assisted Silver Enhancement

Biosensors, 2023
A novel colorimetric aptasensor based on charge effect-assisted silver enhancement was developed to detect ochratoxin A (OTA). To achieve this objective, gold nanoparticles (AuNPs), which can catalyze silver reduction and deposition, were used as the ...
Xiaoyan Yang, Rong Huang, Lulu Xiong, Feng Chen, Wei Sun, Ling Yu   +5 more
doaj   +1 more source

Investigating endogenous µ-opioid receptors in human keratinocytes as pharmacological targets using novel fluorescent ligand. [PDF]

PLoS ONE, 2017
Opioids in skin function during stress response, regeneration, ageing and, particularly in regulating sensation. In chronic pruritus, topical treatment with Naltrexone changes μ-opioid receptor (μ-OR) localization to relieve itch.
Cheryl Leong, Christine Neumann, Srinivas Ramasamy, Bhimsen Rout, Lim Yi Wee, Mei Bigliardi-Qi, Paul L Bigliardi   +6 more
doaj   +1 more source

The Impact of CBLT Approaches on Students' Learning Achievements for ESP Courses

Arbitrer, 2023
ESP courses in higher education are seen as one of the efforts to provide undergraduates with skills beneficial to their careers to meet the growing demand of young professionals.
Muliati Muliati, Syarifuddin Dollah, Tamra Tamra, Ahmad Rossydi, St.Asriati AM   +4 more
doaj   +1 more source

Approbation of the Cancer Treatment Approach Based on the Eradication of TAMRA+ Cancer Stem Cells in a Model of Murine Cyclophosphamide Resistant Lymphosarcoma

Anticancer Research, 2020
Background/Aim: We previously have described the “3+1” tumors cure approach consisting of individual time schedule of cyclophosphamide and dsDNA preparation administrations.
P. E. Kisaretova, S. Kirikovich, G. S. Ritter, Yaroslav R Efremov, O. Taranov, T. D. Dubatolova, A. Proskurina, E. Potter, E. Dolgova, S. Sidorov, A. Ostanin, E. R. Chernych, S. Bogachev   +12 more
semanticscholar   +1 more source

Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids

eLife, 2018
Defining mechanisms of direct-acting antivirals facilitates drug development and our understanding of virus function. Heteroaryldihydropyrimidines (HAPs) inappropriately activate assembly of hepatitis B virus (HBV) core protein (Cp), suppressing ...
Christopher John Schlicksup, Joseph Che-Yen Wang, Samson Francis, Balasubramanian Venkatakrishnan, William W Turner, Michael VanNieuwenhze, Adam Zlotnick   +6 more
doaj   +1 more source