Results 61 to 70 of about 293,472 (265)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Processing system and algorithms for the TanDEM-X mission [PDF]

open access: yes2009 IEEE International Geoscience and Remote Sensing Symposium, 2009
In 2009, the German radar satellite TerraSAR-X will be supplemented with the TanDEM-X satellite to form the first bi-static single pass interferometer in space. TanDEM-X will fly close to TerraSAR-X in a controlled helix configuration for 3 years to jointly acquire interferometric SAR data in bistatic mode.
Breit, Helko   +7 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Results of the TanDEM-X Baseline Calibration

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2013
The TanDEM-X mission based on two satellites provides a radar interferometer in space with the goal to derive a global Digital Elevation Model (DEM) with never achieved quality for a global coverage: a global DEM with a relative height accuracy of 2 m and 10 m absolute.
Walter Antony, John Mohan   +5 more
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Iceberg topography and volume classification using TanDEM-X interferometry [PDF]

open access: yesThe Cryosphere, 2019
Icebergs in polar regions affect water salinity, alter marine habitats, and impose serious hazards on maritime operations and navigation. These impacts mainly depend on the iceberg volume, which remains an elusive parameter to measure. We investigate the
D. O. Dammann   +9 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Bistatic SAR experiments with the TanDEM-X constellation [PDF]

open access: yes2012 IEEE International Geoscience and Remote Sensing Symposium, 2012
Launched in June 2010, TanDEM-X is an interferometric mission with the main goal of providing a high-resolution, global and unprecedentedly accurate digital elevation model (DEM) of the Earth by means of single-pass X-band SAR interferometry. Despite its usual quasi-monostatic configuration, TanDEM-X is the first genuinely bistatic SAR system in space.
Marc Rodriguez-Cassola   +11 more
openaire   +2 more sources

EXTRACTION OF BUILIDNG SHAPE FROM TANDEM-X DATA [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2013
Large scale mapping and modeling of urban areas is requested in many fields, especially in planning of energy supply and for change detection. For this purpose, SAR systems are highly attractive due to their independency of daytime and weather.
A. Thiele   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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