Results 81 to 90 of about 4,674,041 (304)

TANDEM-X height performance and data coverage [PDF]

2017 IEEE International Geoscience and Remote Sensing Symposium (IGARSS), 2017
TanDEM-X is a single-pass radar interferometric mission, which is comprised of two formation flying satellites, with the primary goal of generating a global Digital Elevation Model (DEM) of unprecedented accuracy. Between December 2010 and early 2015 all land surfaces have been acquired at least twice, difficult terrain up to seven or eight times and ...
Wecklich, Christopher, Gonzalez, Carolina, Rizzoli, Paola   +2 more
openaire   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

TanDEM-X: Mission Overview and Status [PDF]

, 2011
TanDEM-X (TerraSAR-X add-on for Digital Elevation Measurements) is an innovative formation flying radar mission that opens a new era in spaceborne radar remote sensing.
Schulze, Daniel, Hajnsek, Irena, Zink, Manfred, Moreira, Alberto, Krieger, Gerhard   +4 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

TanDEM-X Experiments in Pursuit Monostatic Configuration [PDF]

, 2012
This paper reports on several experiments performed by the TanDEM-X constellation that could be potentially implemented as operational modes in future SAR missions.
Steinbrecher, Ulrich, Wollstadt, Steffen, Baumgartner, Stefan, Krieger, Gerhard, Schulze, Daniel, Mittermayer, Josef, Zink, Manfred, Moreira, Alberto, Prats, Pau, Reigber, Andreas, Scheiber, Rolf, López-Dekker, Francisco, Rodríguez-Cassolà, Marc   +12 more
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The TanDEM-X Mission Concept [PDF]

, 2008
TanDEM-X opens a new era in space borne radar remote sensing. The first bistatic SAR mission, is formed by adding a second, almost identical spacecraft, to TerraSAR-X and flying the two satellites in a closely controlled formation with typical distances ...
Zink, Manfred, Moreira, Alberto, Fiedler, Hauke, Krieger, Gerhard   +3 more
core  

TanDEM-X Mission: Overview and Evaluation of intermediate Results [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2013
The German Aerospace Center (DLR, Deutsches Zentrum für Luft- und Raumfahrt) currently conducts the bistatic interferometric synthetic aperture radar (SAR) Mission TanDEM-X, which shall result in a DEM of global coverage in an unprecedented resolution ...
U. Soergel, K. Jacobsen, L. Schack
doaj   +1 more source